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The protein p17 signaling pathways in cancer

Title
The protein p17 signaling pathways in cancer
Author
Klaus Heese
Keywords
Cancer; Oncology; FAM72A; Ugene; p53
Issue Date
2013-12
Publisher
SPRINGER
Citation
TUMOR BIOLOGY, 34, 6, p4081-p4087
Abstract
P17 is a novel neuronal protein expressed under physiological conditions only at very low levels in other tissues. Accumulating data indicate its crucial involvement in tumorigenic effects. Using molecular, cellular, and biocomputational methods, the current study unraveled p17 mode of action. Data indicate that mitochondria-associated p17 interacts with the proteins TMEM115, YPEL3, ERP44, CDK5RAP, and NNAT. Moreover, p17 drives the cell cycle into the G0/G1 phase and enhances survival of proliferating cells. Interference with p17 activities thus might become a novel option to influence also the tumor suppressor protein p53 signaling pathways for the treatment of tumors.
URI
https://link.springer.com/article/10.1007%2Fs13277-013-0999-1http://hdl.handle.net/20.500.11754/45278
ISSN
1010-4283
DOI
10.1007/s13277-013-0999-1
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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