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dc.contributor.author김태형-
dc.date.accessioned2018-03-12T04:09:25Z-
dc.date.available2018-03-12T04:09:25Z-
dc.date.issued2013-07-
dc.identifier.citationRESPIRATION, 권: 86, 호: 2, 페이지: 109-116en_US
dc.identifier.issn0025-7931-
dc.identifier.urihttps://www.karger.com/Article/FullText/342891-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/45244-
dc.description.abstractBackground: To date, no clinical parameter has been associated with the decline in lung function other than emphysema severity in COPD. Objectives: The main purpose of this study was to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation. Methods: A total of 224 subjects were selected from the Korean Obstructive Lung Disease cohort. Exertional desaturation was assessed using the 6-min walk test (6MWT), and defined as a post-exercise oxygen saturation (SpO(2)) of <90% or a >= 4% decrease. The cohort was divided into desaturator (n = 47) and non-desaturator (n = 177) groups. Results: There was a significant difference between the desaturator and non-desaturator groups in terms of the change in pre-bronchodilator forced expiratory volume in 1 s (FEV1) over a 3-year period of follow-up (p = 0.006). The mean rate of decline in FEV1 was greater in the desaturator group (33.8 ml/year) than in the non-desaturator group (11.6 ml/year). A statistically significant difference was also observed between the two groups in terms of the change in the St. George's Respiratory Questionnaire (SGRQ) total score over 3 years (p = 0.001). Conclusions: This study suggests, for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD. Copyright (c) 2012 S. Karger AG, Baselen_US
dc.description.sponsorshipThis study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).en_US
dc.language.isoenen_US
dc.publisherS. Karger AGen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectComputed tomographyen_US
dc.subjectEmphysemaen_US
dc.subjectExertional desaturationen_US
dc.subjectLung functionen_US
dc.titleExertional Desaturation as a Predictor of Rapid Lung Function Decline in COPDen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume86-
dc.identifier.doi10.1159/000342891-
dc.relation.page109-116-
dc.relation.journalRESPIRATION-
dc.contributor.googleauthorKim, Changhwan-
dc.contributor.googleauthorSeo, Joon Beom-
dc.contributor.googleauthorLee, Sang Min-
dc.contributor.googleauthorLee, Jae Seung-
dc.contributor.googleauthorHuh, Jin Won-
dc.contributor.googleauthorLee, Jin Hwa-
dc.contributor.googleauthorRa, Seung Won-
dc.contributor.googleauthorLee, Ji-Hyun-
dc.contributor.googleauthorKim, Eun-Kyung-
dc.contributor.googleauthorKim, Tae-Hyung-
dc.relation.code2013011914-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.piddrterry-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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