Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김태형 | - |
dc.date.accessioned | 2018-03-12T04:09:25Z | - |
dc.date.available | 2018-03-12T04:09:25Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | RESPIRATION, 권: 86, 호: 2, 페이지: 109-116 | en_US |
dc.identifier.issn | 0025-7931 | - |
dc.identifier.uri | https://www.karger.com/Article/FullText/342891 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45244 | - |
dc.description.abstract | Background: To date, no clinical parameter has been associated with the decline in lung function other than emphysema severity in COPD. Objectives: The main purpose of this study was to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation. Methods: A total of 224 subjects were selected from the Korean Obstructive Lung Disease cohort. Exertional desaturation was assessed using the 6-min walk test (6MWT), and defined as a post-exercise oxygen saturation (SpO(2)) of <90% or a >= 4% decrease. The cohort was divided into desaturator (n = 47) and non-desaturator (n = 177) groups. Results: There was a significant difference between the desaturator and non-desaturator groups in terms of the change in pre-bronchodilator forced expiratory volume in 1 s (FEV1) over a 3-year period of follow-up (p = 0.006). The mean rate of decline in FEV1 was greater in the desaturator group (33.8 ml/year) than in the non-desaturator group (11.6 ml/year). A statistically significant difference was also observed between the two groups in terms of the change in the St. George's Respiratory Questionnaire (SGRQ) total score over 3 years (p = 0.001). Conclusions: This study suggests, for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD. Copyright (c) 2012 S. Karger AG, Basel | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065). | en_US |
dc.language.iso | en | en_US |
dc.publisher | S. Karger AG | en_US |
dc.subject | Chronic obstructive pulmonary disease | en_US |
dc.subject | Computed tomography | en_US |
dc.subject | Emphysema | en_US |
dc.subject | Exertional desaturation | en_US |
dc.subject | Lung function | en_US |
dc.title | Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 86 | - |
dc.identifier.doi | 10.1159/000342891 | - |
dc.relation.page | 109-116 | - |
dc.relation.journal | RESPIRATION | - |
dc.contributor.googleauthor | Kim, Changhwan | - |
dc.contributor.googleauthor | Seo, Joon Beom | - |
dc.contributor.googleauthor | Lee, Sang Min | - |
dc.contributor.googleauthor | Lee, Jae Seung | - |
dc.contributor.googleauthor | Huh, Jin Won | - |
dc.contributor.googleauthor | Lee, Jin Hwa | - |
dc.contributor.googleauthor | Ra, Seung Won | - |
dc.contributor.googleauthor | Lee, Ji-Hyun | - |
dc.contributor.googleauthor | Kim, Eun-Kyung | - |
dc.contributor.googleauthor | Kim, Tae-Hyung | - |
dc.relation.code | 2013011914 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | drterry | - |
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