Phase II study of ifosfamide, etoposide, and oxaliplatin (IFETOx) chemotherapy for relapsed or refractory non-Hodgkin's lymphoma.
- Title
- Phase II study of ifosfamide, etoposide, and oxaliplatin (IFETOx) chemotherapy for relapsed or refractory non-Hodgkin's lymphoma.
- Author
- 송무곤
- Keywords
- Non-Hodgkin’s lymphoma; Ifosfamide; Etoposide; Oxaliplatin; Relapse
- Issue Date
- 2013-12
- Publisher
- Springer
- Citation
- International Journal of Hematology, 98권, 5호, 543-548
- Abstract
- As part of an effort to develop a more effective and safe treatment for relapsed or refractory non-Hodgkin’s lymphoma (NHL), we conducted a phase II study of the oxaliplatin, etoposide, and ifosfamide (IFETOx) regimen. Patients with relapsed or refractory NHL and a performance status of 0?2 were eligible. The IFETOx consisted of etoposide at 100 mg/m2 on days 1?3, oxaliplatin at 130 mg/m2 on day 2, and ifosfamide 5,000 mg/m2 on day 2, every 21 days. The primary endpoint was the overall response rate (ORR) for IFETOx regimen. A total of 23 eligible patients were enrolled. The median age was 58 years (range 19?76 years), and the male-to-female ratio was 15:8. The disease status was as follows: 15 patients had relapsed and 8 patients were refractory to treatment. The ORR for IFETOx chemotherapy was 65.2 %. In the 15 patients who responded to the protocol treatment, five underwent hematopoietic stem cell transplantation. The 2-year probability of progression-free survival and overall survival rates were 51.4 and 56.1 %, respectively. Grade 3/4 neutropenia was observed in 73.9 % of the patients. No significant renal impairment was observed. In conclusion, IFETOx chemotherapy shows a tolerable toxicity profile and efficacy as a salvage treatment regimen for relapsed or refractory NHL.
- URI
- https://link.springer.com/article/10.1007%2Fs12185-013-1440-7http://hdl.handle.net/20.500.11754/45242
- ISSN
- 0925-5710; 1865-3774
- DOI
- http://dx.doi.org/10.1007/s12185-013-1440-7
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML