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dc.contributor.author황승용-
dc.date.accessioned2018-03-12T04:02:54Z-
dc.date.available2018-03-12T04:02:54Z-
dc.date.issued2013-12-
dc.identifier.citationBiochip Journal, Vol.7, No.4 [2013], p393-398en_US
dc.identifier.issn1976-0280-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs13206-013-7411-5-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/45234-
dc.description.abstractIn poultry species, H9N2 low pathogenic avian influenza (LPAI) virus infections frequently lead to low to moderate mortality rates and morbidity characterized by depression, respiratory disease symptoms, and decreases in egg production. Since current knowledge on the avian immune response to H9N2 infection is limited, we used microarray analysis to examine global changes in immune-related gene expression induced by H9N2 LPAI infection in specific pathogen-free chickens. The expression profiles of approximately 800 genes, including those that influence cell differentiation, transcription, transport, immune responses, and signal transduction, were altered by H9N2 infection. A complete chicken genome microarray analysis identified a strong innate antiviral host response after infection in spleens. In particular, a significant number of immune response genes, including interferon genes and related immune response genes, were upregulated following H9N2 infection. The increased transcription of 2'-5'-oligoadenylate synthetase and myxovirus resistance genes was confirmed by real-time RT-PCR. These results suggest that the host response generated against H9N2 infection may contribute to protective effects by manipulating innate immune responses.en_US
dc.description.sponsorshipThis research was supported by a Grant from the Korean Rural Development Administration (Agenda Program, 200901OFT072250235).en_US
dc.language.isoenen_US
dc.publisherKorean BioChip Societyen_US
dc.subjectAvian influenza virusen_US
dc.subjectH9N2en_US
dc.subjectMicroarrayen_US
dc.subjectInnate immunityen_US
dc.subjectInterferonen_US
dc.titleInnate immune response gene expression profiles in specific pathogen-free chickens infected with avian influenza virus subtype H9N2en_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume7-
dc.identifier.doi10.1007/s13206-013-7411-5-
dc.relation.page393-398-
dc.relation.journalBIOCHIP JOURNAL-
dc.contributor.googleauthorLee, D. H.-
dc.contributor.googleauthorYuk, S. S.-
dc.contributor.googleauthorPark, J. K.-
dc.contributor.googleauthorKwon, J. H.-
dc.contributor.googleauthorErdene-Ochir, T. O.-
dc.contributor.googleauthorNoh, J. Y.-
dc.contributor.googleauthorYu, S. Y.-
dc.contributor.googleauthorHwang, S. Y.-
dc.contributor.googleauthorLee, S. W.-
dc.contributor.googleauthorSong, C. S.-
dc.relation.code2013001127-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidsyhwang-
dc.identifier.researcherID7404626458-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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