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Serum arylhydrocarbon receptor transactivating activity is elevated in type 2 diabetic patients with diabetic nephropathy

Title
Serum arylhydrocarbon receptor transactivating activity is elevated in type 2 diabetic patients with diabetic nephropathy
Author
전대원
Keywords
Aryl hydrocarbon receptor ligands; Diabetic nephropathy; Persistent organic pollutants
Issue Date
2013-12
Publisher
WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Citation
Journal of Diabetes Investigation, Vol.4, No.5 [2013], p483-491
Abstract
Aims/IntroductionEvidence is emerging that exposure to persistent organic pollutants (POPs) is a risk factor for obesity-related diseases and for diabetes mellitus (DM). We found that POPs could be measured by a cell-based arylhydrocarbon receptor (AhR)-dependent reporter assay. We tested if serum AhR transactivating (AHRT) activities are a risk factor for diabetic nephropathy in people with type 2 diabetes.Materials and MethodsWe enrolled diabetic patients with normoalbuminuria (n=36), microalbuminuria (n=29), macroalbuminuria (n=8) and end-stage renal disease (n=31). Sera were tested for their AHRT activities, which were standardized by an AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and expressed as TCDD equivalents (TCDDeqpmol/L).ResultsMean serum AHRT activities were higher in patients with microalbuminuria (40.1 +/- 7.1pmol/L), macroalbuminuria (37.4 +/- 5.5pmol/L) and end-stage renal disease (59.1 +/- 20.0pmol/L) than in subjects with normoalbuminuria (12.7 +/- 5.4pmol/L; P<0.05 for all comparisons). Serum AhR ligands showed a correlation with estimated glomerular filtration rate (eGFR; r=-0.663, P<0.001), serum creatinine level (r=0.635, P<0.001), systolic blood pressure (r=0.223, P=0.026), glycated hemoglobim (r=0.339, P<0.001) and diabetic duration (r=0.394, P<0.001). In a multiple regression analysis, diabetic nephropathy was found to be an independent risk factor for higher AHRT activity after controlling for the confounding factors.ConclusionsThe present findings suggest serum AHRT activity, thus serum AhR ligands, is a risk factor for diabetic nephropathy. Further studies are required to clarify if an accumulation of POPs in the body is causally related to diabetic nephropathy.
URI
http://onlinelibrary.wiley.com/doi/10.1111/jdi.12081/abstracthttp://hdl.handle.net/20.500.11754/45199
ISSN
2040-1116
DOI
10.1111/jdi.12081
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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