Prediction of VOCs based on functional analysis by decision supporting system

Title
Prediction of VOCs based on functional analysis by decision supporting system
Author
황승용
Keywords
Volatile organic compounds; Decision supporting system; Chemical exposure prediction; Pathway; Biological process
Issue Date
2013-08
Publisher
THE KOREAN SOCIETY OF TOXICOGENOMICS AND TOXICOPRPTEOMICS
Citation
MOLECULAR & CELLULAR TOXICOLOGY, Aug 2013, 9(3), P.277-284
Abstract
In the industrial age, people are exposed to many hazardous substances in many ways. Generally, exposure is of low doses, but chronic symptoms are associated with many industrial pollutants, and therefore, early prediction of exposure is important. In this study, we intended to determine the reliability of the predictive modeling and biomarkers of a previous study, and to determine the related pathway of that biomarkers. We analyzed the key pathways and biological processes associated with volatile organic compounds (VOCs) from previous data - VOCs biomarker CRCT1, RUNX3, PCDH11X and PCSK6. In the analysis, inflammation and neoplasm were remarkably frequently occurring disease within the VOCs exposed body, and especially, exposure to toluene, presents a great likelihood of nerve disease or nervous system disease. Those diseases were related with the several biological processes, they are cell proliferation, apoptosis, inflammatory response, and nervous system development. This study shows probability that application of decision supporting systems, moreover it is helpful to decide whether VOCs exposure has occurred or not, and to predict negative effects.
URI
https://link.springer.com/article/10.1007%2Fs13273-013-0035-yhttp://hdl.handle.net/20.500.11754/45172
ISSN
1738-642X
DOI
10.1007/s13273-013-0035-y
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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