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Antioxidant effect of muscle relaxants (vecuronium, rocuronium) on the rabbit abdominal aortic endothelial damage induced by reactive oxygen species

Title
Antioxidant effect of muscle relaxants (vecuronium, rocuronium) on the rabbit abdominal aortic endothelial damage induced by reactive oxygen species
Other Titles
활성 산소종에 의한 토끼 복부 대동맥의 혈관 내피세포 손상에 미치는 근이완제(Vecuronium, Rocuronium)의 항산화 효과
Author
김동원
Keywords
Antioxidant effect; Reactive oxygen species; Rocuronium; Vecuronium
Issue Date
2013-12
Publisher
대한마취통증의학회
Citation
Korean Journal of Anesthesiology, Vol.65, No.6 [2013], pp552-558
Abstract
Background: Muscle relaxants induce vascular smooth muscle relaxation by inducing synthesis of the prostaglandins that influence vasomotor tone. However, the effects of muscle relaxants on endothelial cells and tissues following injury by reactive oxygen species (ROS) are unclear. We tested the effects of the muscle relaxants vecuronium and rocuronium on impaired acetylcholine (ACh)-induced relaxation following induction of ROS in rabbit aorta in vitro.Methods: Isolated rabbit abdominal aortic ring segments were pretreated with vecuronium or rocuronium at 10-4, 3 × 10-4, 10-3 or 3 × 10-3 M, with or without inhibitors of Cu/Zn superoxide dismutase (diethyldithiocarbamate; DETCA, 0.8 mM) or catalase (3-amino-1,2,4-triazole; 3AT, 50 mM). All groups of aortic rings were then exposed to ROS generated by electrolysis in the organ bath medium (Krebs-Henseleit solution). The effects of vecuronium and rocuronium on ROS-induced impairment of relaxation induced by ACh (10-6 M) were assessed.Results: Aortic rings treated with vecuronium or rocuronium at 10-4, 3 × 10-4, 10-3 or 3 × 10-3 M preserved the capacity for ACh-induced endothelial relaxation following ROS exposure in a dose-dependent manner. Pretreatment with DETCA partially inhibited the protective effects of vecuronium and rocuronium on ACh-induced relaxation (P < 0.001), but pretreatment with 3AT had no effect.Conclusions: Muscle relaxants protected the endothelium in isolated rabbit abdominal aorta from free-radical injury in a dose-dependent manner. These results suggest that vecuronium and rocuronium may act as superoxide anion scavengers.
URI
https://ekja.org/journal/view.php?doi=10.4097/kjae.2013.65.6.552http://hdl.handle.net/20.500.11754/45150
ISSN
2005-6419
DOI
10.4097/kjae.2013.65.6.552
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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