Safety and efficacy of G-CSF mobilization and collection of autologous peripheral blood stem cells in children with cerebral palsy
- Title
- Safety and efficacy of G-CSF mobilization and collection of autologous peripheral blood stem cells in children with cerebral palsy
- Author
- 이영호
- Keywords
- Cerebral palsy; G-CSF; Peripheral blood stem cell; Apheresis
- Issue Date
- 2013-08
- Publisher
- Elsevier Science B.V., Amsterdam.
- Citation
- Transfusion and Apheresis Science December, Aug 2013, 49(3), P.516-521
- Abstract
- We hypothesized that mobilized peripheral blood stem cells (PBSCs) could be useful for treating neurological impairments and therefore assessed the safety of administering G-CSF followed by collecting PBSC in children with cerebral palsy (CP). G-CSF (10 mu g/kg/day) was administered subcutaneously for 5 days, and apheresis was performed to collect PBSC via central venous catheter. G-CSF-related events occurred in 3 patients (fever in 2, irritability in 1). No catheter-related complications were reported. None of the patients needed platelet transfusion or calcium replacement during apheresis. Mobilization with G-CSF followed by PBSC collection appears to be safe and feasible in CP children. (C) 2013 Elsevier Ltd. All rights reserved.
- URI
- http://www.trasci.com/article/S1473-0502(13)00279-6/fulltexthttp://hdl.handle.net/20.500.11754/45125
- ISSN
- 1473-0502
- DOI
- 10.1016/j.transci.2013.08.003
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML