Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최재훈 | - |
dc.date.accessioned | 2018-03-11T02:18:18Z | - |
dc.date.available | 2018-03-11T02:18:18Z | - |
dc.date.issued | 2013-10 | - |
dc.identifier.citation | CIRCULATION RESEARCH, 2013, 113(9), P.1054-1064 | en_US |
dc.identifier.issn | 0009-7330 | - |
dc.identifier.issn | 1524-4571 | - |
dc.identifier.uri | http://circres.ahajournals.org/content/113/9/1054 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/44869 | - |
dc.description.abstract | Rationale: Quantitative trait locus mapping of an intercross between C57.Apoe(-/-) and FVB.Apoe(-/-) mice revealed an atherosclerosis locus controlling aortic root lesion area on proximal chromosome 10, Ath11. In a previous work, subcongenic analysis showed Ath11 to be complex with proximal (10a) and distal (10b) regions.Objective: To identify the causative genetic variation underlying the atherosclerosis modifier locus Ath11 10b.Methods and Results: We now report subcongenic J, which narrows the 10b region to 5 genes, Myb, Hbs1L, Aldh8a1, Sgk1, and Raet1e. Sequence analysis of these genes revealed no amino acid coding differences between the parental strains. However, comparing aortic expression of these genes between F1.Apoe(-/-) Chr10SubJ((B/F)) and F1.Apoe(-/-) Chr10SubJ((F/F)) uncovered a consistent difference only for Raet1e, with decreased, virtually background, expression associated with increased atherosclerosis in the latter. The key role of Raet1e was confirmed by showing that transgene-induced aortic overexpression of Raet1e in F1.Apoe(-/-) Chr10SubJ((F/F)) mice decreased atherosclerosis. Promoter reporter constructs comparing C57 and FVB sequences identified an FVB mutation in the core of the major aortic transcription start site abrogating activity.Conclusions: This nonbiased approach has revealed Raet1e, a major histocompatibility complex class 1-like molecule expressed in lesional aortic endothelial cells and macrophage-rich regions, as a novel atherosclerosis gene and represents one of the few successes of the quantitative trait locus strategy in complex diseases. | en_US |
dc.description.sponsorship | This research was supported by National Institutes of Health grants P01-HL54591 and R01-HL107342. | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA | en_US |
dc.subject | atherosclerosis | en_US |
dc.subject | gene expression | en_US |
dc.subject | genetic susceptibility | en_US |
dc.subject | mice | en_US |
dc.subject | mouse model | en_US |
dc.subject | quantitative trait loci | en_US |
dc.subject | GENOME-WIDE ASSOCIATION | en_US |
dc.subject | CORONARY-ARTERY-DISEASE | en_US |
dc.subject | QUANTITATIVE TRAIT LOCI | en_US |
dc.subject | NKG2D LIGAND EXPRESSION | en_US |
dc.subject | SUSCEPTIBILITY LOCUS | en_US |
dc.subject | CELL-PROLIFERATION | en_US |
dc.subject | LABORATORY MOUSE | en_US |
dc.subject | NATURAL-KILLER | en_US |
dc.subject | DEFICIENT MICE | en_US |
dc.subject | T-CELLS | en_US |
dc.title | Altered Expression of Raet1e, a Major Histocompatibility Complex Class 1-Like Molecule, Underlies the Atherosclerosis Modifier Locus Ath11 10b | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 113 | - |
dc.identifier.doi | 10.1161/CIRCRESAHA.113.302052 | - |
dc.relation.page | 1054-1064 | - |
dc.relation.journal | CIRCULATION RESEARCH | - |
dc.contributor.googleauthor | Rodriguez, Jose M. | - |
dc.contributor.googleauthor | Wolfrum, Susanne | - |
dc.contributor.googleauthor | Robblee, Megan | - |
dc.contributor.googleauthor | Chen, Kwan Y. | - |
dc.contributor.googleauthor | Gilbert, Zachary N. | - |
dc.contributor.googleauthor | Choi, Jae-Hoon | - |
dc.contributor.googleauthor | Teupser, Daniel | - |
dc.contributor.googleauthor | Breslow, Jan L. | - |
dc.relation.code | 2013009429 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | jchoi75 | - |
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