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기도점막 수지상 세포의 역할

Title
기도점막 수지상 세포의 역할
Other Titles
Role of Dendritic Cells in the Airway Mucosa
Author
조석현
Keywords
인체; 폐질환; 과민반응; Dendritic Cells; Lung Diseases; Hypersensitivity, Humans
Issue Date
2013-02
Publisher
한양대학교
Citation
Hanyang Medical Reviews, 33, 1, 45-51
Abstract
Dendritic cells (DC) are located at the environment-host interface and are continuously exposed to a vast array of foreign proteins and pathogens. The major role of DC is to sample environmental antigens and then to migrate to regional lymph nodes where they present processed antigenic peptides to T cells. Therefore, DC can polarize naive T cells into either Th1 or Th2 effector cells and have a central role in coordinating the balance between immunity and tolerance to inhaled antigens. DC studies can be difficult to perform, because there is no specific cell surface marker for DC. Furthermore, they are a minor population in blood and tissue, and show heterogeneity (many subtypes) and remarkable functional plasticity (immature and mature types). Many DC experiments performed in mouse models may be very different in human disease. There are still unknown questions regarding origin, function, and the molecular events governing their characteristic features. Therefore, better understanding of human DC biology will allow us in the future to use DC as a new therapeutic target for refractory airway diseases including asthma, allergic rhinitis and chronic rhinosinusitis with polyposis.
URI
https://synapse.koreamed.org/DOIx.php?id=10.7599/hmr.2013.33.1.45http://hdl.handle.net/20.500.11754/44849
ISSN
1738-429X
DOI
10.7599/hmr.2013.33.1.45
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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