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Voluntary movements as a possible non-reflexive pain assay

Title
Voluntary movements as a possible non-reflexive pain assay
Author
김성민
Keywords
Voluntary movement; Rearing; Total distance moved; Inflammatory pain; Neuropathic pain; Visceral pain; TRPV1
Issue Date
2013-05
Publisher
Biomed Central LTD
Citation
Molecular Pain, 2013, 9, P.25
Abstract
Background: The quantification of pain intensity in vivo is essential for identifying the mechanisms of various types of pain or for evaluating the effects of different analgesics. A variety of behavioral tests for pain measurement have been devised, but many are limited because animals are physically restricted, which affects pain sensation. In this study, pain assessment was attempted with minimal physical restriction, and voluntary movements of unrestrained animals were used to evaluate the intensities of various types of pain. Results: The number of times animals reared or total distances traveled was measured using a motion-tracking device and found to be markedly reduced in carrageenan-induced inflammatory, acetic acid-induced visceral, and streptozotocin-induced neuropathic pain tests. These two voluntary movement parameters were found to be highly correlated with paw withdrawal latency from irradiating heat. In addition, these parameters were markedly reversed by morphine and by non-steroidal anti-inflammatory drugs in inflammatory pain models. These parameters were also useful to detect hypoalgesia in TRPV1(-/-) mice. Conclusions: These results suggest that parameters of voluntary movement, such as, number of rearing and total distance moved, are effective indicators of pain intensity for many types of pain and that they can be used to evaluate degree of pain perception.
URI
http://journals.sagepub.com/doi/10.1186/1744-8069-9-25http://hdl.handle.net/20.500.11754/44793
ISSN
1744-8069
DOI
10.1186/1744-8069-9-25
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COLLEGE OF ART AND PHYSICAL EDUCATION[S](예술·체육대학) > PHYSICAL EDUCATION(체육학과) > Articles
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