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Drug Delivery Systems for the Treatment of Ischemic Stroke

Title
Drug Delivery Systems for the Treatment of Ischemic Stroke
Author
이민형
Keywords
brain; drug delivery; gene delivery; ischemia; stroke; BLOOD-BRAIN-BARRIER; FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; RECOMBINANT ADENOASSOCIATED VIRUS; VEGF GENE DELIVERY; ACUTE INTRACEREBRAL HEMORRHAGE; HEME OXYGENASE-1 PREVENTS; POLYMER-COATED ADENOVIRUS; FIBROBLAST-GROWTH-FACTOR; MESENCHYMAL STEM-CELLS
Issue Date
2013-10
Publisher
Springer Science+Business Media New York 2013
Citation
PHARMACEUTICAL RESEARCH, 2013, 30(10), P.2429-2444
Abstract
Stroke is the third leading cause of death in the United States. Reduced cerebral blood flow causes acute damage to the brain due to excitotoxicity, reactive oxygen species (ROS), and ischemia. Currently, the main treatment for stroke is to revive the blood flow by using thrombolytic agents. Reviving blood flow also causes ischemia-reperfusion (I/R) damage. I/R damage results from inflammation and apoptosis and can persist for days to weeks, increasing the infarct size. Drugs can be applied to stroke to intervene in the sub-acute and chronic phases. Chemical, peptide, and genetic therapies have been evaluated to reduce delayed damage to the brain. These drugs have different characteristics, requiring that delivery carriers be developed based on these characteristics. The delivery route is another important factor affecting the efficiency of drug delivery. Various delivery routes have been developed, such as intravenous injection, intranasal administration, and local direct injection to overcome the blood-brain-barrier (BBB). In this review, the delivery carriers and delivery routes for peptide and gene therapies are discussed and examples are provided. Combined with new drugs, drug delivery systems will eventually provide useful treatments for ischemic stroke.
URI
http://link.springer.com/article/10.1007%2Fs11095-012-0959-2http://hdl.handle.net/20.500.11754/44735
ISSN
0724-8741
DOI
10.1007/s11095-012-0959-2
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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