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근거중심 한국형 우울증 약물학적 치료지침, 개정판(II): 항우울제의 위약대비 효과

Title
근거중심 한국형 우울증 약물학적 치료지침, 개정판(II): 항우울제의 위약대비 효과
Author
최준호
Keywords
Major depressive disorder; Guideline; Antidepressant; Placebo; Difference in efficacy; Appropriate time; Efficacy judgment
Issue Date
2013-09
Publisher
대한신경정신의학회(THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)
Citation
神經精神醫學(JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION), Vol.52 No.5 [2013], 372-385
Abstract
Objectives The purpose of this study was to suggest recommendations of antidepressant efficacy compared with placebo, difference in efficacy of antidepressants, and appropriate time of efficacy judgment in antidepressant therapy.Methods Using recommendations from 12 international and domestic clinical practice guidelines for depression, drawing of recommendation drafts, and peer review, the executive committee developed the guideline.Results Tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOI), selective serotonin reuptake inhibitors (SSRI), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and specific serotonergic antidepressants (NaSSAs), norepinephrine and dopamine reuptake inhibitors (NDRIs), and serotonin antagonist and reuptake inhibitors (SARIs) were strongly recommended as having antidepressant efficacy compared with placebo. Difference in efficacy of antidepressants was as follows. TCAs, MAOI, SSRI, SNRIs, and NaSSAs were strongly recommended, however, NDRIs, SARIs were weakly recommended. If there was no or minimal improvement with treatment, appropriate time of efficacy judgment in antidepressant therapy was estimated to be after two to four weeks.Conclusion We hope that the results of this study will be helpful in encouraging the optimal treatment by understanding antidepressant efficacy compared with placebo, difference in efficacy of antidepressants, and appropriate time of efficacy judgment in antidepressant therapy.
URI
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001812129http://hdl.handle.net/20.500.11754/44673
ISSN
1015-4817
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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