Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하태경 | - |
dc.date.accessioned | 2018-03-10T03:51:18Z | - |
dc.date.available | 2018-03-10T03:51:18Z | - |
dc.date.issued | 2013-05 | - |
dc.identifier.citation | Korean Journal of Radiology, MAR-APR 2013, 14(2), P.375-p383 | en_US |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://synapse.koreamed.org/search.php?where=aview&id=10.3348/kjr.2013.14.2.375&code=0068KJR&vmode=FT | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/44620 | - |
dc.description.abstract | Objective: To identify CT and FDG-PET features associated with epidermal growth factor receptor (EGFR) protein overexpression, and to evaluate whether imaging features and EGFR-overexpression can help predict clinical outcome. Materials and Methods: In 214 patients (M : F = 129 : 85; mean age, 63.2) who underwent curative resection of stage I non-small cell Lung cancer, EGFR protein expression status was determined through immunohistochemical analysis. Imaging characteristics on CT and FDG-PET was assessed in relation to EGFR-overexpression. Imaging features and EGFR-overexpression were also evaluated for clinical outcome by using the Cox proportional hazards model. Results: EGFR-overexpression was found in 51 patients (23.8%). It was significantly more frequent in tumors with an SUVmax > 5.0 (p < 0.0001), diameter > 2.43 cm (p < 0.0001), and with ground glass opacity <= 50% (p = 0.0073). SUVmax > 5.0 (OR, 3.113; 95% CI, 1.375-7.049; p = 0.006) and diameter > 2.43 cm (OR, 2.799; 95% CI, 1.285-6.095; p = 0.010) were independent predictors of EGFR-overexpression. Multivariate analysis showed that SUVmax > 4.0 (hazard ratio, 10.660; 95% CI, 1.370-82.966; p = 0.024), and the presence of cavitation within a tumor (hazard ratio, 3.122; 95% CI, 1.143-8.532; p = 0.026) were factors associated with poor prognosis. Conclusion: EGFR-overexpression is associated with high SUVmax, Large tumor diameter, and small GGO proportion. CT and FDG-PET findings, which are closely related to EGFR overexpression, can be valuable in the prediction of clinical outcome. | en_US |
dc.language.iso | en | en_US |
dc.publisher | The Korean Society of Radiology | en_US |
dc.subject | EGFR | en_US |
dc.subject | EGFR protein | en_US |
dc.subject | CT | en_US |
dc.subject | FDG-PET | en_US |
dc.subject | Non-small cell lung cancer | en_US |
dc.title | Imaging Characteristics of Stage I Non-Small Cell Lung Cancer on CT and FDG-PET: Relationship with Epidermal Growth Factor Receptor Protein Expression Status and Survival | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 14 | - |
dc.identifier.doi | 10.3348/kjr.2013.14.2.375 | - |
dc.relation.page | 375-383 | - |
dc.relation.journal | KOREAN JOURNAL OF RADIOLOGY | - |
dc.contributor.googleauthor | Kim, Young Tae | - |
dc.contributor.googleauthor | Jeon, Yoon Kyung | - |
dc.contributor.googleauthor | Chung, Doo Hyun | - |
dc.contributor.googleauthor | Lee, Youkyung | - |
dc.contributor.googleauthor | Kang, Chang Hyun | - |
dc.contributor.googleauthor | Goo, Jin Mo | - |
dc.contributor.googleauthor | Lee, Hyun-Ju | - |
dc.contributor.googleauthor | Paeng, Jin Chul | - |
dc.contributor.googleauthor | Park, Chang Min | - |
dc.relation.code | 2013005805 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | missurgeon | - |
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