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Body Fat Distribution After Menopause and Cardiovascular Disease Risk Factors: Korean National Health and Nutrition Examination Survey 2010

Title
Body Fat Distribution After Menopause and Cardiovascular Disease Risk Factors: Korean National Health and Nutrition Examination Survey 2010
Author
신진호
Keywords
Adipose Tissue Distribution; Postmenopause; Cardiovascular Risk Factors
Issue Date
2013-05
Publisher
MARY ANN LIEBERT, INC, 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
Citation
Journal of Women's Health, Vol.22, No.7 [2013], p587-594
Abstract
Background: The prevalence of cardiovascular disease in women increases sharply after menopause. The purpose of this study was to clarify the relationship between menopause and body fat distribution and to investigate their association with cardiovascular disease risk factors. Methods: We analyzed 2035 women 20-79 years of age using the National Health and Nutrition Examination Survey (KNHANES) 2010 database. Body fat was measured using dual-energy X-ray absorptiometry. Results: The percentage of total body fat and the body fat distribution (BFD) index (the ratio of the trunk fat mass to leg fat mass) are significantly higher in postmenopausal women than in premenopausal women (all p<0.001). When adjusted for age, menopause was associated with higher total body fat percentage (adjusted β=1.082, 95% confidence interval [CI] 0.074-2.090, p=0.035). In women with a body mass index<25 kg/m2, the higher BFD index was also independently associated with menopause (adjusted β=14.408, 95% CI 1.672-27.145, p=0.027). After adjusting for age and body fat percentage, the BFD index showed significant and independent associations with systolic and diastolic blood pressure (adjusted β=0.060 and 0.042, all p<0.001, respectively), fasting glucose (adjusted β=0.007, p<0.001), total and high density lipoprotein cholesterol (adjusted β=0.001 and ?0.002, p<0.05 and p<0.001, respectively), and triglyceride levels (adjusted β=0.007, p<0.001- except for low density lipoprotein cholesterol. Conclusions: After menopause, women have not only higher total body fat percentage but also its different distribution, which independently correlates with cardiovascular disease risk factors. Therefore, this change in body fat may cause the sharp increase in cardiovascular disease incidence in middle-aged women, especially after menopause.
URI
http://online.liebertpub.com/doi/abs/10.1089/jwh.2012.4035http://hdl.handle.net/20.500.11754/44603
ISSN
1540-9996
DOI
10.1089/jwh.2012.4035
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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