Superoxide Anion Production by Human Neutrophils Activated by Trichomonas vaginalis

Title
Superoxide Anion Production by Human Neutrophils Activated by Trichomonas vaginalis
Author
류재숙
Keywords
Trichomonas vaginalis; neutrophil; superoxide anion; myeloperoxidase; growth inhibition
Issue Date
2013-08
Publisher
대한기생충학열대의학회
Citation
The Korean journal of parasitology. Aug 2013, 51(4), P.479-484
Abstract
Neutrophils are the predominant inflammatory cells found in vaginal discharges of patients infected with Trichomonas vaginalis. In this study, we examined superoxide anion (O.2-) production by neutrophils activated by T. vaginalis. Human neutrophils produced superoxide anions when stimulated with either a lysate of T. vaginalis, its membrane component (MC), or excretory-secretory product (ESP). To assess the role of trichomonad protease in production of superoxide anions by neutrophils, T. vaginalis lysate, ESP, and MC were each pretreated with a protease inhibitor cocktail before incubation with neutrophils. Superoxide anion production was significantly decreased by this treatment. Trichomonad growth was inhibited by preincubation with supernatants of neutrophils incubated for 3 hr with T. vaginalis lysate. Furthermore, myeloperoxidase (MPO) production by neutrophils was stimulated by live trichomonads. These results indicate that the production of superoxide anions and MPO by neutrophils stimulated with T. vaginalis may be a part of defense mechanisms of neutrophils in trichomoniasis.
URI
http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2013.51.4.479http://hdl.handle.net/20.500.11754/44507
ISSN
0023-4001; 1738-0006
DOI
10.3347/kjp.2013.51.4.479
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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