ATP-Binding Cassette Sterol Transporters Are Differentially Expressed in Normal and Diseased Human Gallbladder

Title
ATP-Binding Cassette Sterol Transporters Are Differentially Expressed in Normal and Diseased Human Gallbladder
Author
최호순
Keywords
Gallbladder epithelial cell; ABCA1; ABCG5; ABCG8
Issue Date
2013-02
Publisher
Springer
Citation
Digestive diseases and sciences, 58, 2, 431 - 439
Abstract
Gallbladder epithelial cells (GBEC) are exposed to high cholesterol concentrations in bile, and export cholesterol via an ATP-binding cassette (ABC) transporter-mediated pathway in vitro. These findings suggest that aberrant expression and/or function of ABC sterol transporters may be associated with cholesterol-related gallbladder diseases (CAGD). In this study, we investigated the relative levels of the sterol transporters ABCA1, ABCG5, and ABCG8 in human gallbladders in CAGD, and the relationship between ABCA1 and inflammation.
URI
https://link.springer.com/article/10.1007/s10620-012-2481-0http://hdl.handle.net/20.500.11754/44444
ISSN
0163-2116
DOI
10.1007/s10620-012-2481-0
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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