The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism

Title
The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism
Authors
김연제
Keywords
Congenital hypothyroidism; Endocrine disruptors; Isoflavones; Association; GC?MS
Issue Date
2013-03
Publisher
Elsevier
Citation
Environmental Toxicology and Pharmacology, 35, 2, 278-283
Abstract
Congenital hypothyroidism is a common pediatric endocrine disease. Endocrine disruptors are indicated as a possible cause of congenital hypothyroidism. We investigated the associations between endocrine disruptors and the occurrence of congenital hypothyroidism and passage of target compounds from the mother. The levels of phthalates (DEHP, MEHP, DBP, MBP and PA), alkylphenols (n-NP and t-OP), bisphenol, and isoflavones (equol, daidzein and genistein) were determined by gas chromatography?mass spectrometry (GC?MS) in infants. t-OP and PA concentrations in the patient group were significantly higher than in normal infants. Genistein concentrations in normal infants were significantly higher than in patients. We compared the plasma levels of target compounds in infants with their mothers. There was no correlation with the passage of endocrine disruptors and isoflavones from the mothers, except for t-OP, which was weakly correlated between mother and infant.
URI
https://www.sciencedirect.com/science/article/pii/S1382668913000033http://hdl.handle.net/20.500.11754/44358
ISSN
1382-6689
DOI
http://dx.doi.org/10.1016/j.etap.2013.01.002
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > RESEARCH INSTITUTE OF INDUSTRIAL SCIENCE(산업과학연구소) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE