Acteoside improves survival in cecal ligation and puncture-induced septic mice via blocking of high mobility group box 1 release

Title
Acteoside improves survival in cecal ligation and puncture-induced septic mice via blocking of high mobility group box 1 release
Author
김영필
Keywords
acteoside; heme oxygenase 1; high-mobility group box 1; nrf2; p38; Raw264.7 cell; sepsis
Issue Date
2013-04
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, April 2013, 35(4), P.348-354
Abstract
Acteoside, an active phenylethanoid glycoside, has been used traditionally as an anti-inflammatory agent. The molecular mechanism by which acteoside reduces inflammation was investigated in lipopolysaccharide (LPS)-induced Raw264.7 cells and in a mouse model of cecal ligation and puncture (CLP)-induced sepsis. In vitro, acteoside inhibits high mobility group box 1 (HMGB1) release and iNOS/NO production and induces heme oxygenase-1 (HO-1) expression in a concentration-dependent manner, while HO-1 siRNA antagonizes the inhibition of HMGB1 and NO. The effect of acteoside is inhibited by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 and Nfr2 siRNA, indicating that acteoside induces HO-1 via p38 MAPK and NF-E2-related factor 2 (Nrf2). In vivo, acteoside increases survival and decreases serum and lung HMGB1 levels in CLP-induced sepsis. Overall, these results that acteoside reduces HMGB1 release and may be beneficial for the treatment of sepsis.
URI
http://link.springer.com/article/10.1007%2Fs10059-013-0021-1http://hdl.handle.net/20.500.11754/44328
ISSN
1016-8478
DOI
10.1007/s10059-013-0021-1
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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