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Formation of polymersomes with double bilayers templated by quadruple emulsions

Title
Formation of polymersomes with double bilayers templated by quadruple emulsions
Author
김진웅
Keywords
MONODISPERSE DOUBLE EMULSIONS; MICROFLUIDIC DEVICES; MULTIPLE EMULSIONS; TRIGGERED RELEASE; FABRICATION; VESICLES; SHELLS; MICROCAPSULES; PERMEABILITY; DYNAMICS
Issue Date
2013-04
Publisher
Royal Society of Chemistry
Citation
LAB ON A CHIP, April 2013, 13(7), P.1351-1356
Abstract
Polymersomes, vesicles composed of bilayer membranes of amphiphilic block-copolymers, are promising delivery vehicles for long-term storage and controlled release of bioactives; enhanced stability of the membrane makes polymersomes potentially useful in a wide range of biological delivery applications by comparison with liposomes. However, unilamellar structure is intrinsically fragile when subjected to external stress. Here, we report a microfluidic approach to produce polymersomes with double bilayers, providing higher stability and lower permeability than unilamellar polymersomes. To achieve this, we developed a new design of a capillary microfluidic device to produce quadruple-emulsion drops which serve as a template for the polymersomes-in-polymersomes. When two bilayers are attracted by depletion in polymersomes-in-polymersomes, the inner polymersomes protrude and bud, forming double bilayers. We confirm these structures are indeed double bilayers using microaspiration and selective doping of the leaflets with nanoparticles. The resultant polymersomes have great potential as highly stable and biocompatible microcarriers for robust encapsulation and storage of bioactives such as drugs, cosmetics and nutrients.
URI
http://pubs.rsc.org/en/Content/ArticleLanding/2013/LC/c3lc41112e#!divAbstracthttp://hdl.handle.net/20.500.11754/44326
ISSN
1473-0197
DOI
10.1039/c3lc41112e
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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