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Diffusion Behaviors of Fluorescence Probe Molecules Through the Stratum Corneum Layer Under Physical Stress

Title
Diffusion Behaviors of Fluorescence Probe Molecules Through the Stratum Corneum Layer Under Physical Stress
Author
김진웅
Keywords
Physical stress; Skin permeability; Projection; Stratum corneum
Issue Date
2013-04
Publisher
SPRINGER
Citation
JOURNAL OF MEMBRANE BIOLOGY, April 2013, 246(4), P.263-269
Abstract
This study experimentally demonstrates how application of an external physical stress onto the skin membrane affects the permeation of penetrating molecules. As a proxy of active compounds, in this study, a series of fluorescence probe molecules were utilized. We observed that skin permeation could be enhanced by imparting vertical strokes from a tapping head consisting of projections onto the skin. This was confirmed with consistency from in vitro and in vivo transdermal permeation studies. After an effective physical stress was applied to the skin, the permeation depth of probe molecules remarkably increased, which was comparable to the case of topical treatment. This seems to arise from temporal disordering of the stratum corneum layer in response to the applied physical stress.
URI
http://link.springer.com/article/10.1007%2Fs00232-013-9527-xhttp://hdl.handle.net/20.500.11754/44323
ISSN
0022-2631
DOI
10.1007/s00232-013-9527-x
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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