Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동윤 | - |
dc.date.accessioned | 2018-03-09T06:04:51Z | - |
dc.date.available | 2018-03-09T06:04:51Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | BIOMATERIALS SCIENCE 권: 1 호: 7 페이지: 783-790 | en_US |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | http://dx.doi.org/10.1039/c3bm00004d | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/44239 | - |
dc.description | Molecular-level Interface Research Center | en_US |
dc.description.abstract | This report describes a simple method to prepare water-soluble chitosan derivative by conjugation of an enediol group, catechol. Chitosan functionalized with a catechol-containing compound, 3,4-dihydroxy-hydrocinnamic acid, by a carbodiimide coupling method resulted in chitosan-catechol conjugates. This one-step chemical modification of high-molecular-weight chitosan (approximately 100 kDa) dramatically increased the water solubility of the chitosan derivative to 60 mg mL(-1) at pH 7.0. The degree of catechol conjugation was found critical in determining the solubility. The chitosan-catechol conjugates are not only water-soluble but are adhesive, due to the intrinsic adhesive properties of catechol. Also, the water-soluble chitosan derivative allows one to directly form chitosan hydrogel in neutral buffer solutions. The utility of both the water solubility and the adhesive property of the chitosan-catechol was demonstrated by the effective layer-by-layer assembly on substrates. The water-soluble chitosan-catechol is expected to be useful in many areas of surface functionalization, drug delivery, tissue engineering, and tissue adhesives. | en_US |
dc.description.sponsorship | WCU program | en_US |
dc.language.iso | en | en_US |
dc.publisher | ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND | en_US |
dc.subject | GLYCOL CHITOSAN | en_US |
dc.subject | POLY(ETHYLENE GLYCOL) | en_US |
dc.subject | MOLECULAR-WEIGHT | en_US |
dc.subject | SURFACE | en_US |
dc.subject | SOLUBILITY | en_US |
dc.subject | POLYMER | en_US |
dc.subject | ACID | en_US |
dc.subject | BIODISTRIBUTION | en_US |
dc.subject | ACETYLATION | en_US |
dc.subject | PEGYLATION | en_US |
dc.title | Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly | en_US |
dc.type | Article | en_US |
dc.relation.no | 7 | - |
dc.relation.volume | 1 | - |
dc.identifier.doi | 10.1039/c3bm00004d | - |
dc.relation.page | 783-790 | - |
dc.relation.journal | Biomaterials Science | - |
dc.contributor.googleauthor | Kim, Kyuri | - |
dc.contributor.googleauthor | Ryu, Ji Hyun | - |
dc.contributor.googleauthor | Lee, Dong Yun | - |
dc.contributor.googleauthor | Lee, Haeshin | - |
dc.relation.code | 2014002140 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | dongyunlee | - |
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