Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly
- Title
- Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly
- Author
- 이동윤
- Keywords
- GLYCOL CHITOSAN; POLY(ETHYLENE GLYCOL); MOLECULAR-WEIGHT; SURFACE; SOLUBILITY; POLYMER; ACID; BIODISTRIBUTION; ACETYLATION; PEGYLATION
- Issue Date
- 2013-07
- Publisher
- ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
- Citation
- BIOMATERIALS SCIENCE 권: 1 호: 7 페이지: 783-790
- Abstract
- This report describes a simple method to prepare water-soluble chitosan derivative by conjugation of an enediol group, catechol. Chitosan functionalized with a catechol-containing compound, 3,4-dihydroxy-hydrocinnamic acid, by a carbodiimide coupling method resulted in chitosan-catechol conjugates. This one-step chemical modification of high-molecular-weight chitosan (approximately 100 kDa) dramatically increased the water solubility of the chitosan derivative to 60 mg mL(-1) at pH 7.0. The degree of catechol conjugation was found critical in determining the solubility. The chitosan-catechol conjugates are not only water-soluble but are adhesive, due to the intrinsic adhesive properties of catechol. Also, the water-soluble chitosan derivative allows one to directly form chitosan hydrogel in neutral buffer solutions. The utility of both the water solubility and the adhesive property of the chitosan-catechol was demonstrated by the effective layer-by-layer assembly on substrates. The water-soluble chitosan-catechol is expected to be useful in many areas of surface functionalization, drug delivery, tissue engineering, and tissue adhesives.
- Description
- Molecular-level Interface Research Center
- URI
- http://dx.doi.org/10.1039/c3bm00004dhttp://hdl.handle.net/20.500.11754/44239
- ISSN
- 2047-4830
- DOI
- 10.1039/c3bm00004d
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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