48 5

Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast

Title
Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast
Author
백승삼
Keywords
cell adhesion molecule; cell adhesion molecule 4; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; unclassified drug
Issue Date
2013-07
Publisher
BRITISH MEDICAL ASSOC
Citation
Journal of Clinical Pathology,2013,66(8),p681-686
Abstract
Aims Cell adhesion molecule 4 (CADM4) is a novel tumour suppressor involved in cell adhesion. Loss or decreased expression of CADM4 has been associated with the development and progression of some cancers. The purpose of this study was to investigate the clinicopathological significance of CADM4 expression in breast cancer.Methods We constructed tissue microarrays to evaluate the immunohistochemical expression of CADM4 in 256 cases of invasive ductal carcinoma (IDC) and 45 cases of ductal carcinoma in situ (DCIS).Results CADM4 was expressed in 37 (82.2%) DCIS cases, and in 173 (67.6%) IDC cases. CADM4 expression was higher in DCIS than in IDC (p=0.049). Loss or decrease of CADM4 expression was significantly correlated with higher histological grade (p=0.020), absence of oestrogen receptors (p<0.001), absence of progesterone receptors (p=0.024), and overexpression of c-erbB-2 (p=0.018). In univariable and multivariable Cox regression analyses of all 256 IDC cases, CADM4 expression was not significantly associated with overall and disease-free survival. However, it showed a significant positive association with longer disease-free survival in 187 stages I and II IDC cases (p=0.039, log-rank test).Conclusions Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters. CADM4 can be used as a novel marker predicting risk of recurrence and disease outcomes in stages I and II IDC.
URI
http://synapse.koreamed.org/DOIx.php?id=10.4048/jbc.2015.18.1.1
ISSN
0021-9746
DOI
10.1136/jclinpath-2012-201405
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
jbc-18-1.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE