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Proteomic Analysis of the Oxidative Stress Response Induced by Low-Dose Hydrogen Peroxide in Bacillus anthracis

Title
Proteomic Analysis of the Oxidative Stress Response Induced by Low-Dose Hydrogen Peroxide in Bacillus anthracis
Author
채영규
Keywords
Bacillus anthracis; hydrogen peroxide; oxidative stress; proteomics
Issue Date
2013-07
Publisher
한국미생물 · 생명공학회
Citation
Journal of Microbiology and Biotechnology, Vol.23, No.6 [2013], p750-758
Abstract
Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis, which is an important pathogen owing to its ability to be used as a terror agent. B. anthracis spores can escape phagocytosis and initiate the germination process even in antimicrobial conditions, such as oxidative stress. To analyze the oxidative stress response in B. anthracis and thereby learn how to prevent antimicrobial resistance, we performed protein expression profiling of B. anthracis strain HY1 treated with 0.3 mM hydrogen peroxide using a comparative proteomics-based approach. The results showed a total of 60 differentially expressed proteins; among them, 17 showed differences in expression over time. We observed time-dependent changes in the production of metabolic and repair/protection signaling proteins. These results will be useful for uncovering the metabolic pathways and protection mechanisms of the oxidative response in B. anthracis.
URI
http://www.jmb.or.kr/journal/viewJournal.html?year=2013&vol=23&num=6&page=750http://hdl.handle.net/20.500.11754/44033
ISSN
1017-7825
DOI
10.4014/jmb.1209.09070
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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