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Waveform analysis of tremor may help to differentiate Parkinson's disease from drug-induced parkinsonism

Title
Waveform analysis of tremor may help to differentiate Parkinson's disease from drug-induced parkinsonism
Author
김희태
Keywords
Parkinson's disease; drug-induced parkinsonism; tremor; accelerometry
Issue Date
2013-02
Publisher
IOP Publishing LTD
Citation
Physiological Measurement, Mar 2013, 34(3), P.N15-N24
Abstract
In this study, we analyzed the waveform characteristics of resting tremor by accelerometer recordings in patients with drug-induced parkinsonism (DIP) and Parkinson's disease (PD). We prospectively recruited 12 patients with tremulous PD and 12 patients with DIP presenting with resting tremor. Tremor was recorded from the more affected side and was recorded twice for a 60 s period in each patient. Peak frequency, amplitude and all harmonic peaks were obtained, and the asymmetry of the decay of the autocorrelation function, third momentum and time-reversal invariance were also computed using a mathematical algorithm. Among the parameters used in the waveform analysis, the harmonic ratio, time-reversal invariance and asymmetric decay of the autocorrelation function were different between PD and DIP at a statistically significant level (all p < 0.01). The total harmonic peak power and third momentum in the time series were not significantly different. The clinical characteristics of DIP patients may be similar to those of PD patients in some cases, which makes the clinical differentiation between DIP and PD challenging. Our study shows that the identification of parameters reflecting waveform asymmetry might be helpful in differentiating between DIP and PD.
URI
http://iopscience.iop.org/article/10.1088/0967-3334/34/3/N15/metahttp://hdl.handle.net/20.500.11754/43960
ISSN
0967-3334
DOI
10.1088/0967-3334/34/3/N15
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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