Polymersomes Containing a Hydrogel Network for High Stability and Controlled Release
- Title
- Polymersomes Containing a Hydrogel Network for High Stability and Controlled Release
- Author
- 김진웅
- Keywords
- polymersomes; microfluidics; hydrogels; controlled release; emulsions
- Issue Date
- 2013-01
- Publisher
- WILEY-V C H VERLAG GMBH
- Citation
- Small, 2013, 9(1), P.124-131
- Abstract
- Capillary microfluidic devices are used to prepare monodisperse polymersomes consisting of a hydrogel core and a bilayer membrane of amphiphilic diblock-copolymers. To make polymersomes, water-in-oil-in-water double-emulsion drops are prepared as templates through single-step emulsification in a capillary microfluidic device. The amphiphile-laden middle oil phase of the double-emulsion drop dewets from the surface of the innermost water drop, which contains hydrogel prepolymers; this dewetting leads to the formation of a bilayer membrane. Subsequently, the oil phase completely separates from the innermost water drop, leaving a polymersome. Upon UV illumination of the polymersome, the prepolymers encapsulated within the interior are crosslinked, forming a hydrogel core. The hydrogel network within the polymersomes facilitates sustained release of the encapsulated materials and increases the stability of the polymersomes through the formation of a scaffold to support the bilayer. In addition, this approach provides a facile method to make monodisperse hydrogel particles directly dispersed in water.
- URI
- http://onlinelibrary.wiley.com/doi/10.1002/smll.201201709/abstracthttp://hdl.handle.net/20.500.11754/43634
- ISSN
- 1613-6810
- DOI
- 10.1002/smll.201201709
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML