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dc.contributor.author신인철-
dc.date.accessioned2018-03-07T00:15:43Z-
dc.date.available2018-03-07T00:15:43Z-
dc.date.issued2012-11-
dc.identifier.citationCELLULAR SIGNALLING, Vol.24, No.11 [2012], p2132-2142en_US
dc.identifier.issn0898-6568-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0898656812001957?via%3Dihub-
dc.description.abstractTo determine the role of CD24 in breast cancer cells, we knocked down CD24 in MCF-7 human breast cancer cells by retroviral delivery of shRNA. MCF-7 cells with knocked down CD24 (MCF-7 hCD24 shRNA) exhibited decreased cell proliferation and cell adhesion as compared to control MCF-7 mCD24 shRNA cells. Decreased proliferation of MCF-7 hCD24 shRNA cells resulted from the inhibition of cell cycle progression from G1 to S phase. The specific inhibition of MEK/ERK signaling by CD24 ablation might be responsible for the inhibition of cell proliferation. Phosphorylation of Src/FAK and TGF-beta 1 -mediated epithelial to mesenchymal transition was also down-regulated in MCF-7 hCD24 shRNA cells. Reduced Src/FAK activity was caused by a decrease in integrin beta 1 bound with CD24 and subsequent destabilization of integrin beta 1. Our results suggest that down-regulation of Raf/MEK/ERK signaling via Src/FAK may be dependent on integrin beta 1 function and that this mechanism is largely responsible for the CD24 ablation-induced decreases in cell proliferation and epithelial to mesenchymal transition. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by Converging Research Center Program (2011-K000897), the NRF grant (2011-0015515) and Basic Research Program of the Korea Science and Engineering Foundation (2008-05943).en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAen_US
dc.subjectCD24en_US
dc.subjectEMTen_US
dc.subjectERKen_US
dc.subjectFAKen_US
dc.subjectIntegrinen_US
dc.subjectFOCAL ADHESION KINASEen_US
dc.subjectBREAST-CANCER CELLSen_US
dc.subjectINDEPENDENT PROGNOSTIC MARKERen_US
dc.subjectTGF-BETAen_US
dc.subjectC-SRCen_US
dc.subjectSIGNALING PATHWAYSen_US
dc.subjectPROTEIN-KINASEen_US
dc.subjectIN-VITROen_US
dc.subjectB-CELLSen_US
dc.subjectEXPRESSIONen_US
dc.titleCD24 regulates cell proliferation and transforming growth factor beta-induced epithelial to mesenchymal transition through modulation of integrin beta 1 stabilityen_US
dc.typeArticleen_US
dc.relation.no11-
dc.relation.volume24-
dc.identifier.doi10.1016/j.cellsig.2012.07.005-
dc.relation.page2132-2142-
dc.relation.journalCELLULAR SIGNALLING-
dc.contributor.googleauthorLee, Kyung-Min-
dc.contributor.googleauthorJu, Ji-Hyun-
dc.contributor.googleauthorJang, Ki-Beom-
dc.contributor.googleauthorYang, Won-Seok-
dc.contributor.googleauthorYi, Jae-Youn-
dc.contributor.googleauthorNoh, Dong-Young-
dc.contributor.googleauthorShin, In-Cheol-
dc.relation.code2012201756-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidincheol-
dc.identifier.researcherID21735691700-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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