Structure-based de novo design of Eya2 phosphatase inhibitors
- Title
- Structure-based de novo design of Eya2 phosphatase inhibitors
- Author
- 류성언
- Keywords
- De novo design; Eya2 phosphatase; Inhibitor; Chelating group; Anticancer agents
- Issue Date
- 2012-11
- Publisher
- Elsevier Science INC
- Citation
- Journal of Molecular Graphics and Modelling, 2012, 38, P.382-388
- Abstract
- Although Eyes absent protein tyrosine phosphatases proved to be involved in various human cancers by a series of persuasive experimental evidence, only a very few number of small-molecule inhibitors have been reported so far. We have been able to identify 29 novel inhibitors of Eyes absent homologue 2 (Eya2) by means of a structure-based de novo design with the two known inhibitor scaffolds that contain a proper chelating group for the active-site Mg2+ ion. Because these newly found inhibitors were screened for having desirable physicochemical properties as a drug candidate and exhibited a moderate inhibitory activity with IC50 values ranging from 6 to 50 mu M, they deserve consideration for further investigation to develop new anticancer medicines. Structural features relevant to the stabilization of the identified inhibitors in the active site of Eya2 phosphatase are discussed in detail. (C) 2012 Elsevier Inc. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S1093326312000551?via%3Dihubhttp://hdl.handle.net/20.500.11754/42987
- ISSN
- 1093-3263
- DOI
- 10.1016/j.jmgm.2012.05.003
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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