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NSAIDs and radiographic progression in ankylosing spondylitis

Title
NSAIDs and radiographic progression in ankylosing spondylitis
Author
김태환
Keywords
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; BONE-MINERAL DENSITY; SYNDESMOPHYTE FORMATION; PROSTAGLANDIN E-2; SPINAL-FUSION; OLDER WOMEN; SPONDYLOARTHRITIS; RECOMMENDATIONS; DICKKOPF-1; MANAGEMENT
Issue Date
2012-12
Publisher
BMJ PUBLISHING GROUP
Citation
Annals of the rheumatic diseases,Vol.71,No.10 [2012],p1593-1595
Abstract
a subsequent study hinted at a possible increase in risk of fractures in NSAID users despite an increase in BMD. 9 Analysis of the Canadian Multicentre Osteoporosis Study on the effects of NSAIDs on BMD led to interesting findings. 10 The use of NSAIDs was associated with a decrease in BMD in men and increase in postmenopausal women who did not receive oestrogen replacement. 10 The authors concluded that the effect of NSAIDs seen in this study is a reflection of suppression of inflammation associated with the postmenopausal state, while the direct effect of prostaglandin inhibition on bone is manifest in men as a decrease in BMD. [...]there are few studies to inform the decision on whether NSAIDs should be continued when a biological agent is administered, although our recent experience provides supportive evidence for this approach. 4 Both for the pivotal phase 3 random control trials of biological agents in AS and current third-party coverage, inadequate control of symptoms by NSAIDs has become the criteria for use of anti-TNF agents. [...]the published literature on the effects of anti-TNF agents on bone formation is based largely on experience with NSAID non-responders.
URI
http://search.proquest.com/docview/1778067035?accountid=11283http://hdl.handle.net/20.500.11754/42932
ISSN
0003-4967
DOI
10.1136/annrheumdis-2012-201844
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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