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dc.contributor.author박용수-
dc.date.accessioned2018-03-05T08:36:26Z-
dc.date.available2018-03-05T08:36:26Z-
dc.date.issued2012-11-
dc.identifier.citationDIABETES, Vol.61, No.11 [2012], p2932 ~ 2938en_US
dc.identifier.issn0012-1797-
dc.identifier.urihttp://diabetes.diabetesjournals.org/content/61/11/2932-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/42723-
dc.description.abstractRecent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors. ⓒ 2012 by the American Diabetes Association.en_US
dc.description.sponsorshipK.M.C. was supported by the Mid-Career Researcher Program through a National Research Foundation of Korea grant funded by the Ministry of Education, Science, and Technology of the Korean government (R01-2007-000-20546-0), the Korean Health 21 R&D Project, and the Ministry of Health and Welfare, Republic of Korea (A050463). K.M.C. and S.H.B. were supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).B.-S.Y. is employed by AdipoGen, Inc. No other potential conflicts of interest relevant to this article were reported.K.M.C. researched the data and wrote the manuscript. S.Y.H., H.C.H., S.J.Y., H.Y.C., and H.J.Y. researched the data. K.W.L., M.S.N., Y.S.P., J.T.W., and Y.S.K. contributed to the discussion and reviewed and edited the manuscript. D.S.C., B.-S.Y., and S.H.B. researched the data and reviewed and edited the manuscript. K.M.C. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.en_US
dc.language.isoenen_US
dc.publisherMEDLINE/PubMeden_US
dc.subjectAdulten_US
dc.subjectAtherosclerosisen_US
dc.subjectepidemiologyen_US
dc.subjectetiologyen_US
dc.subjectBiomarkersen_US
dc.subjectblooden_US
dc.subjectBody Mass Indexen_US
dc.subjectCohort Studiesen_US
dc.subjectCross-Sectional Studiesen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectType 2en_US
dc.subjectmetabolismen_US
dc.subjectphysiopathologyen_US
dc.subjectDyslipidemiasen_US
dc.subjectEye Proteinsen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectHypertensionen_US
dc.subjectInsulin Resistanceen_US
dc.subjectMaleen_US
dc.subjectMetabolic Syndrome Xen_US
dc.subjectMiddle Ageden_US
dc.subjectNerve Growth Factorsen_US
dc.subjectObesityen_US
dc.subjectPrediabetic Stateen_US
dc.subjectPrevalenceen_US
dc.subjectRepublic of Koreaen_US
dc.subjectRisk Factorsen_US
dc.subjectSerpinsen_US
dc.subjectTumor Necrosis Factorsen_US
dc.titleC1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndromeen_US
dc.typeArticleen_US
dc.relation.no11-
dc.relation.volume61-
dc.identifier.doi10.2337/db12-0217-
dc.relation.page2932-2936-
dc.relation.journalDIABETES-
dc.contributor.googleauthorChoi, Kyung-Mook-
dc.contributor.googleauthorHwang, Soon-Young-
dc.contributor.googleauthorHong, Ho-Cheol-
dc.contributor.googleauthorYang, Sae-Jeong-
dc.contributor.googleauthorChoi, Hae-Yoon-
dc.contributor.googleauthorYoo, Hye-Jin-
dc.contributor.googleauthorLee, Kwan-Woo-
dc.contributor.googleauthorNam, Moon-Suk-
dc.contributor.googleauthorPark, Yong-Soo-
dc.contributor.googleauthorWoo, Jeong-Taek-
dc.relation.code2012202552-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidparkys-
dc.identifier.researcherID55702168800-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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