Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박용수 | - |
dc.date.accessioned | 2018-03-05T08:36:26Z | - |
dc.date.available | 2018-03-05T08:36:26Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | DIABETES, Vol.61, No.11 [2012], p2932 ~ 2938 | en_US |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://diabetes.diabetesjournals.org/content/61/11/2932 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/42723 | - |
dc.description.abstract | Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors. ⓒ 2012 by the American Diabetes Association. | en_US |
dc.description.sponsorship | K.M.C. was supported by the Mid-Career Researcher Program through a National Research Foundation of Korea grant funded by the Ministry of Education, Science, and Technology of the Korean government (R01-2007-000-20546-0), the Korean Health 21 R&D Project, and the Ministry of Health and Welfare, Republic of Korea (A050463). K.M.C. and S.H.B. were supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).B.-S.Y. is employed by AdipoGen, Inc. No other potential conflicts of interest relevant to this article were reported.K.M.C. researched the data and wrote the manuscript. S.Y.H., H.C.H., S.J.Y., H.Y.C., and H.J.Y. researched the data. K.W.L., M.S.N., Y.S.P., J.T.W., and Y.S.K. contributed to the discussion and reviewed and edited the manuscript. D.S.C., B.-S.Y., and S.H.B. researched the data and reviewed and edited the manuscript. K.M.C. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MEDLINE/PubMed | en_US |
dc.subject | Adult | en_US |
dc.subject | Atherosclerosis | en_US |
dc.subject | epidemiology | en_US |
dc.subject | etiology | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | blood | en_US |
dc.subject | Body Mass Index | en_US |
dc.subject | Cohort Studies | en_US |
dc.subject | Cross-Sectional Studies | en_US |
dc.subject | Diabetes Mellitus | en_US |
dc.subject | Type 2 | en_US |
dc.subject | metabolism | en_US |
dc.subject | physiopathology | en_US |
dc.subject | Dyslipidemias | en_US |
dc.subject | Eye Proteins | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Insulin Resistance | en_US |
dc.subject | Male | en_US |
dc.subject | Metabolic Syndrome X | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Nerve Growth Factors | en_US |
dc.subject | Obesity | en_US |
dc.subject | Prediabetic State | en_US |
dc.subject | Prevalence | en_US |
dc.subject | Republic of Korea | en_US |
dc.subject | Risk Factors | en_US |
dc.subject | Serpins | en_US |
dc.subject | Tumor Necrosis Factors | en_US |
dc.title | C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 61 | - |
dc.identifier.doi | 10.2337/db12-0217 | - |
dc.relation.page | 2932-2936 | - |
dc.relation.journal | DIABETES | - |
dc.contributor.googleauthor | Choi, Kyung-Mook | - |
dc.contributor.googleauthor | Hwang, Soon-Young | - |
dc.contributor.googleauthor | Hong, Ho-Cheol | - |
dc.contributor.googleauthor | Yang, Sae-Jeong | - |
dc.contributor.googleauthor | Choi, Hae-Yoon | - |
dc.contributor.googleauthor | Yoo, Hye-Jin | - |
dc.contributor.googleauthor | Lee, Kwan-Woo | - |
dc.contributor.googleauthor | Nam, Moon-Suk | - |
dc.contributor.googleauthor | Park, Yong-Soo | - |
dc.contributor.googleauthor | Woo, Jeong-Taek | - |
dc.relation.code | 2012202552 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | parkys | - |
dc.identifier.researcherID | 55702168800 | - |
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