83 0

C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome

Title
C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome
Author
박용수
Keywords
Adult; Atherosclerosis; epidemiology; etiology; Biomarkers; blood; Body Mass Index; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Type 2; metabolism; physiopathology; Dyslipidemias; Eye Proteins; Female; Humans; Hypertension; Insulin Resistance; Male; Metabolic Syndrome X; Middle Aged; Nerve Growth Factors; Obesity; Prediabetic State; Prevalence; Republic of Korea; Risk Factors; Serpins; Tumor Necrosis Factors
Issue Date
2012-11
Publisher
MEDLINE/PubMed
Citation
DIABETES, Vol.61, No.11 [2012], p2932 ~ 2938
Abstract
Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors. ⓒ 2012 by the American Diabetes Association.
URI
http://diabetes.diabetesjournals.org/content/61/11/2932http://hdl.handle.net/20.500.11754/42723
ISSN
0012-1797
DOI
10.2337/db12-0217
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE