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Analysis of toxicity of tetrabutyltin: comparing with EDC chemicals

Title
Analysis of toxicity of tetrabutyltin: comparing with EDC chemicals
Author
황승용
Keywords
Tetrabutyltin; HazChem Human array; Toxicity; Endotoxic; NONYLPHENOL; ENVIRONMENT
Issue Date
2011-03
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT, HANYANG UNIV, SCI & TECHNOL BLDG 1, RM 423, SA-DONG, SANGROK-GU, ANSAN, GYEONGGI-DO, 426 791, SOUTH KOREA
Citation
MOLECULAR AND CELLULAR TOXICOLOGY,Vol.7 No.1 [2011],95-101
Abstract
Exposure to environmental chemicals has been implicated in a number of adverse health effects, including immunotoxic, neurotoxic, reproductive toxic effects, and, above all, cancers. In the present study, we investigated toxicity of three environmental chemicals-bisphenol A (BPA), nonylphenol (NP), and tetrabutyltin (TTBT) in a human breast cancer cell line by HazChem Human array. We then found toxicity markers of TTBT through comparison with BPA and NP. Fifty three genes were differentially expressed and seventeen genes showed similar expression patterns. Ontology analysis showed differential expression of genes related to aging and apoptosis and genes having similarities associated with pregnancy and insemination. In this paper, we revealed potential TTBT toxic markers and endotoxicity of TTBT. This study could be a foundation for additional studies of TIBT toxicity.
URI
https://link.springer.com/article/10.1007%2Fs13273-011-0013-1
ISSN
1738-642X
DOI
10.1007/s13273-011-0013-1
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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