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Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells

Title
Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells
Author
채영규
Keywords
apoptosis; cell cycle; cellular proliferation; pargyline; prostate cancer cells; BREAST-CANCER; POLYAMINE ANALOG; BCL-2 FAMILY; APOPTOSIS; DEATH; LSD1; RECRUITMENT; COMBINATION; NOXA
Issue Date
2013-10
Publisher
SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE
Citation
Oncology Reports. (Oncology Reports, October 2013, 30(4),p1587-1592
Abstract
Chemotherapy is one of the therapeutic strategies that has been used for the inhibition of cancer cell proliferation in several types of cancer, including prostate cancer. Although monoamine oxidase (MAO) inhibitors, phytoestrogen and antioxidants used in chemotherapy have been systematically studied, their effects on cancer cell growth remain to be fully understood. The purpose of this study was to investigate the effects of the MAO inhibitors, pargyline and tranylcypromine on cell survival in human prostate carcinoma (LNCaP-LN3) cells. After treating LNCaP-LN3 cells with pargyline or tranylcypromine, we examined cell proliferation, cell cycle pattern, apoptosis and the expression levels of apoptosis-related genes. The proliferation of cells exposed to pargyline decreased in a dose-and time-dependent manner, while tranylcypromine-treated cells showed the opposite results. Treatment with pargyline significantly induced cell cycle arrest at the G1 phase compared to the control and tranylcypromine-treated cells. In addition, pargyline induced an increase in the cell death rate by promoting apoptosis; however, tranylcypromine had no effect on LNCaP-LN3 cells. Based on our results, we suggest that pargyline is more powerful than tranylcypromine for the treatment of human prostate cancer.
URI
https://doi.org/10.3892/or.2013.2635http://hdl.handle.net/20.500.11754/42231
ISSN
1021335X; 17912431
DOI
10.3892/or.2013.2635
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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