Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 채영규 | - |
dc.date.accessioned | 2018-02-28T08:23:31Z | - |
dc.date.available | 2018-02-28T08:23:31Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF TOXICOLOGY,Vol.31,No.4 [2012],p397-406 | en_US |
dc.identifier.issn | 1091-5818 | - |
dc.identifier.uri | http://journals.sagepub.com/doi/10.1177/1091581812446869 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/41348 | - |
dc.description.abstract | Excessive exposure to copper, a redox-active metal, generates free radicals, which can cause cellular damage. In this study, we aim to identify the proteins that are up- or downregulated by copper exposure in human embryonic carcinoma (NCCIT) cells and to understand the mechanisms that play a role in the copper-induced stress response. After exposure to copper ions, the cells showed upregulated levels of 78 kDa glucose-regulated protein, fibrillin 1, CWC22 spliceosome-associated protein (KIAA1604), heat shock protein (HSP) 60, and HSP70, while the tumor necrosis factor receptor-associated factor 6, vimentin, 14-3-3 protein zeta, and RAC-beta (AKT2) serine/threonine protein kinase were downregulated. The GeneGo Process Networks of the proteins upregulated by copper ions were analyzed, and the 3 highest-scoring networks from the proteins upregulated by copper ions are presented here. In particular, the increased level of HSP70 in response to copper ions occurred in a dose-dependent manner, indicating that HSP70 could be a potential biomarker for copper toxicity in mammalian cells. | en_US |
dc.description.sponsorship | The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: the National Research Foundation of Korea Grant funded by the Korean Government (No. 2011-0030768) and a grant of the Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A101712). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Informa Healthcare | en_US |
dc.subject | copper | en_US |
dc.subject | HSP70 | en_US |
dc.subject | NCCIT cells | en_US |
dc.subject | protein profiling | en_US |
dc.subject | 14-3-3 protein zeta | en_US |
dc.subject | HEMATOPOIETIC PROGENITOR CELLS | en_US |
dc.subject | STEM-CELLS | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | PROTEINS | en_US |
dc.subject | DIFFERENTIATION | en_US |
dc.subject | ZEBRAFISH | en_US |
dc.subject | INCREASES | en_US |
dc.subject | DISEASE | en_US |
dc.subject | GENES | en_US |
dc.subject | DOCK8 | en_US |
dc.title | Proteomic analysis of the copper ion-induced stress response in a human embryonic carcinoma cell line | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 31 | - |
dc.identifier.doi | 10.1177/1091581812446869 | - |
dc.relation.page | 397-406 | - |
dc.relation.journal | International Journal of Toxicology | - |
dc.contributor.googleauthor | Han, Dal Mu Ri | - |
dc.contributor.googleauthor | Choi, Mi-Ran | - |
dc.contributor.googleauthor | Jung, Kyoung-Hwa | - |
dc.contributor.googleauthor | Lee, Hyung-Tae | - |
dc.contributor.googleauthor | Park, Ji-Hyun | - |
dc.contributor.googleauthor | Ohn, Takbum | - |
dc.contributor.googleauthor | Chai, Young-Gyu | - |
dc.relation.code | 2012250870 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | ygchai | - |
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