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N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test

Title
N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test
Author
박용순
Keywords
BDNF; CREB; Cytokines; Depression; Forced swimming test; n-3 polyunsaturated fatty acids; EICOSAPENTAENOIC ACID; MAJOR DEPRESSION; DOUBLE-BLIND; FEMALE RATS; HIPPOCAMPUS; OMEGA-3-FATTY-ACIDS; SEROTONIN; NEUROTRANSMISSION; PHOSPHOLIPIDS; DEPRIVATION
Issue Date
2012-08
Publisher
Elsevier Science B.V., Amsterdam
Citation
The Journal of nutritional biochemistry,Vol.23,No.8 [2012],p924-928
Abstract
Epidemiological data and clinical trials suggest that n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have preventive and therapeutic effects on depression; however, the underlying mechanism remains elusive. The present study aimed to examine the behavioral effects and antidepressant mechanism of n-3 PUFA using a forced swimming test. Eleven-week-old male Sprague Dawley rats were fed an American Institute of Nutrition-93M diet containing 0%, 0.5% or 1% EPA and DHA relative to the total energy intake in their diet for 12 weeks (n=8 per group). Total dietary intake, body weight and hippocampus weights were not significantly different among groups. The groups administered 0.5% and 1% EPA+DHA diets had significantly higher levels of n-3 PUFA in their brain phospholipids compared to those in the control group. The immobility time was significantly decreased and the climbing time was significantly increased in the 0.5% and 1% EPA+DHA groups compared with those in the 0% EPA+DHA group. Plasma serotonin concentration and hippocampus c-AMP response element binding protein (CREB) expression were significantly increased in the 0.5% and 1% EPA+DHA groups compared with those in the 0% EPA+DHA group. Conversely, interleukin (IL)-6 expression was significantly reduced in the 0.5% and 1% EPA+DHA groups compared with that in the 0% EPA+DHA group. However, there were no dose-dependent effects of n-3 PUFA and no significant differences in expressions of IL-1 beta, tumor necrosis factor-alpha, brain-derived neurotrophic factor or phosphorylated CREB. In conclusion, long-term intake of EPA+DHA induced antidepressant-like effects in rats and overexpression of CREB via decreased IL-6 expression. (C) 2012 Elsevier Inc. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0955286311001458?via%3Dihubhttp://hdl.handle.net/20.500.11754/41310
ISSN
0955-2863
DOI
10.1016/j.jnutbio.2011.04.018
Appears in Collections:
COLLEGE OF HUMAN ECOLOGY[S](생활과학대학) > FOOD & NUTRITION(식품영양학과) > Articles
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