Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안강호 | - |
dc.date.accessioned | 2018-02-28T06:05:02Z | - |
dc.date.available | 2018-02-28T06:05:02Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.citation | BIOMED RESEARCH INTERNATIONAL, v. 2015, Article ID 376756 | en_US |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.issn | 2314-6141 | - |
dc.identifier.uri | https://www.hindawi.com/journals/bmri/2015/376756/ | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/41242 | - |
dc.description.abstract | Graphene is receiving increased attention due to its potential widespread applications in future. However, the health effects of graphene have not yet been well studied. Therefore, this study examined the pulmonary effects of graphene oxide using male Sprague-Dawley rats and a single 6-hour nose-only inhalation technique. Following the exposure, the rats were allowed to recover for 1 day, 7 days, or 14 days. A total of three groups were compared: control (fresh air), low concentration (0.46 + 0.06 mg/m(3)), and high concentration (3.76 +/- 0.24 mg/m(3)). The exposure to graphene oxide did not induce significant changes in the body weights, organ weights, and food consumption during the 14 days of recovery time. The microalbumin and lactate dehydrogenase levels in the bronchoalveolar lavage (BAL) fluid were not significantly changed due to the exposure. Similarly, total cell count, macrophages, polymorphonuclear leukocytes, and lymphocytes were not significantly altered in the BAL fluid. Plus, the histopathological examination of the rat lungs only showed an uptake of graphene oxide in the alveolar macrophages of the high-concentration group. Therefore, these results demonstrate that the single inhalation exposure to graphene oxide induce minimal toxic responses in rat lungs at the concentrations and time points used in the present study. | en_US |
dc.description.sponsorship | This research was supported by the NanoMaterial Technology Development Program (2014M3A7B6020163) of MSIP/NRF and supported by the Industrial Strategic Technology Development Program (10047829, Development of Technologies on Testing Evaluation Method and Standardization for Nanoproduct and Nanomaterial) funded by the Ministry of Trade, Industry & Energy (MI, Korea). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | HINDAWI PUBLISHING CORPORATION | en_US |
dc.subject | WALLED CARBON NANOTUBES | en_US |
dc.subject | NANOPLATELETS | en_US |
dc.subject | NANOPARTICLES | en_US |
dc.subject | TOXICITY | en_US |
dc.subject | CELLS | en_US |
dc.title | Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials | en_US |
dc.type | Article | en_US |
dc.relation.volume | 2015 | - |
dc.identifier.doi | 10.1155/2015/376756 | - |
dc.relation.page | 1-9 | - |
dc.relation.journal | BIOMED RESEARCH INTERNATIONAL | - |
dc.contributor.googleauthor | Han, Sung Gu | - |
dc.contributor.googleauthor | Kim, Jin Kwon | - |
dc.contributor.googleauthor | Shin, Jae Hoon | - |
dc.contributor.googleauthor | Hwang, Joo Hwan | - |
dc.contributor.googleauthor | Lee, Jong Seong | - |
dc.contributor.googleauthor | Kim, Tae-Gyu | - |
dc.contributor.googleauthor | Lee, Ji Hyun | - |
dc.contributor.googleauthor | Lee, Gun Ho | - |
dc.contributor.googleauthor | Kim, Keun Soo | - |
dc.contributor.googleauthor | Ahn, Kangho | - |
dc.contributor.googleauthor | Lee, Heon Sang | - |
dc.contributor.googleauthor | Song, Nam Woong | - |
dc.contributor.googleauthor | Yu, Il Je | - |
dc.relation.code | 2015012204 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF ENGINEERING SCIENCES[E] | - |
dc.sector.department | DEPARTMENT OF MECHANICAL ENGINEERING | - |
dc.identifier.pid | khahn | - |
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