Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials
- Title
- Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials
- Author
- 안강호
- Keywords
- WALLED CARBON NANOTUBES; NANOPLATELETS; NANOPARTICLES; TOXICITY; CELLS
- Issue Date
- 2015-10
- Publisher
- HINDAWI PUBLISHING CORPORATION
- Citation
- BIOMED RESEARCH INTERNATIONAL, v. 2015, Article ID 376756
- Abstract
- Graphene is receiving increased attention due to its potential widespread applications in future. However, the health effects of graphene have not yet been well studied. Therefore, this study examined the pulmonary effects of graphene oxide using male Sprague-Dawley rats and a single 6-hour nose-only inhalation technique. Following the exposure, the rats were allowed to recover for 1 day, 7 days, or 14 days. A total of three groups were compared: control (fresh air), low concentration (0.46 + 0.06 mg/m(3)), and high concentration (3.76 +/- 0.24 mg/m(3)). The exposure to graphene oxide did not induce significant changes in the body weights, organ weights, and food consumption during the 14 days of recovery time. The microalbumin and lactate dehydrogenase levels in the bronchoalveolar lavage (BAL) fluid were not significantly changed due to the exposure. Similarly, total cell count, macrophages, polymorphonuclear leukocytes, and lymphocytes were not significantly altered in the BAL fluid. Plus, the histopathological examination of the rat lungs only showed an uptake of graphene oxide in the alveolar macrophages of the high-concentration group. Therefore, these results demonstrate that the single inhalation exposure to graphene oxide induce minimal toxic responses in rat lungs at the concentrations and time points used in the present study.
- URI
- https://www.hindawi.com/journals/bmri/2015/376756/http://hdl.handle.net/20.500.11754/41242
- ISSN
- 2314-6133; 2314-6141
- DOI
- 10.1155/2015/376756
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MECHANICAL ENGINEERING(기계공학과) > Articles
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