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dc.contributor.author임동우-
dc.date.accessioned2018-02-28T05:51:16Z-
dc.date.available2018-02-28T05:51:16Z-
dc.date.issued2012-09-
dc.identifier.citationInternational Journal of Pharmaceutics, Sep 2012, 434(1-2), P.488-493en_US
dc.identifier.issn0378-5173-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S037851731200470X?via%3Dihub-
dc.description.abstractCancer chemotherapy is often limited, since more than one molecule is usually involved with the cancer pathogenesis. A combination of therapeutic drugs would be a promising approach to overcome the complexity of tumors. In this study, a conjugate (DA3) of deoxycholic acid and low molecular weight polyethylenimine (PEI 1.8 kDa), which has a property that mimics that of cell penetrating peptides (CPPs), was used for simultaneous delivery of an anticancer drug and siRNA. When complexed with siRNA, DA3 showed significantly higher target gene silencing efficiency than PEI 25 kDa. The gene silencing efficiency of DA3 was maintained even in the presence of endocytosis inhibitors, suggesting that the polymeric carrier can mediate an endocytosis-independent macromolecular transduction similar to CPPs. The capability of forming a micelle-like core-shell structure enables the conjugates to encapsulate and dissolve paclitaxel (PTX), a water-insoluble drug. The drug-loaded cationic micelles can then interact with siRNA to form stable complexes (PTX/DA3/siRNA). The PTX/DA3/siRNA showed significantly enhanced inhibition of cancer cell growth. When administered into tumor-bearing animals, the PTX/DA3/siRNA demonstrated significant suppression of tumor growth, providing potential usefulness in clinical settings.en_US
dc.description.sponsorshipThis research was supported by the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2011-0019775, 2009-0088722, 2010-0027955, and 2011-0093632) and by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs (A110879).en_US
dc.language.isoenen_US
dc.publisherElsevier Science BVen_US
dc.subjectBiomimetic polymeren_US
dc.subjectCombined deliveryen_US
dc.subjectsiRNAen_US
dc.subjectAnticancer drugen_US
dc.subjectCombination cancer therapyen_US
dc.titleCell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppressionen_US
dc.typeArticleen_US
dc.relation.no1-2-
dc.relation.volume434-
dc.identifier.doi10.1016/j.ijpharm.2012.04.083-
dc.relation.page488-493-
dc.relation.journalINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.contributor.googleauthorJang, Yeon Lim-
dc.contributor.googleauthorYun, Ui Jeong-
dc.contributor.googleauthorLee, Min Sang-
dc.contributor.googleauthorKim, Myung Goo-
dc.contributor.googleauthorSon, Sohee-
dc.contributor.googleauthorLee, Kyuri-
dc.contributor.googleauthorChae, Su Young-
dc.contributor.googleauthorJeong, Ji Hoon-
dc.contributor.googleauthorLim, Dong Woo-
dc.contributor.googleauthorKim, Hong Tae-
dc.contributor.googleauthorKim, Sun Hwa-
dc.contributor.googleauthor장연임-
dc.contributor.googleauthor연위정-
dc.contributor.googleauthor이민상-
dc.contributor.googleauthor김명구-
dc.contributor.googleauthor손소희-
dc.contributor.googleauthor이규리-
dc.contributor.googleauthor채수영-
dc.contributor.googleauthor정지훈-
dc.contributor.googleauthor임동우-
dc.contributor.googleauthor김홍태-
dc.contributor.googleauthor김선화-
dc.relation.code2012204294-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.piddlim-
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