102 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author안주홍-
dc.date.accessioned2018-02-28T04:37:54Z-
dc.date.available2018-02-28T04:37:54Z-
dc.date.issued2011-05-
dc.identifier.citationFEBS Letters 6 May 2011, 585(9),1310-1316en_US
dc.identifier.issn0014-5793-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2011.03.062/abstract-
dc.description.abstractDicarbonyl/L-xylulose reductase (DCXR) converts L-xylulose into xylitol, and reduces variousa-dicar-bonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxi?cation. Inthis study, we identi?ed DHS-21 as the only DCXR ortholog in Caenorhabditis elegans. The dhs-21gene is expressed in various tissues including the intestine, gonadal sheath cells, uterine seam (utse)cells, the spermathecal-uterus (sp-ut) valve and on the plasma membrane of spermatids. Recombi-nant DHS-21 was shown to convertL-xylulose to xylitol using NADPH as a cofactor. Dhs-21 mutants of C. elegans show defects in longevity, reproduction and egg-laying. Knock-down of daf-16 and elt-2 transcription factors affected dhs-21 expression. These results suggest that DHS-21 isa bona ?de DCXR of C. elegans, essential for normal life span and reproduction.en_US
dc.description.sponsorshipWe gratefully acknowledge the Caenorhabditis Genetic Centerfor nematode strains, A. Fire for vectors, Yuji Kohara for yk clonesand Akira Hara for the rat DXCR cDNA. We also thank AndrewSingson and Christopher Rongo for sharing their research facilities.This study was supported by a fellowship from the Vietnamesegovernment (11/2006/QD-TTg and 1893/QD-BNN-TCCB; L.T.S.),Women Scientists Program (No. 2010-0006121; S-.K.Lee), andWorld Class University Program (No. R33-2008-000-10026-0;J. Ahnn) from the National Research Foundation of Korea.en_US
dc.language.isoenen_US
dc.publisherElsevier Science B.V., Amsterdamen_US
dc.subjectdhs-21en_US
dc.subjectL-Xylulose reductaseen_US
dc.subjectLongevityen_US
dc.subjectEgg-layingen_US
dc.subjectGene expressionen_US
dc.titleDHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegansen_US
dc.title.alternativeL-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegansen_US
dc.typeArticleen_US
dc.relation.no9-
dc.relation.volume585-
dc.identifier.doi10.1016/j.febslet.2011.03.062-
dc.relation.page1310-1316-
dc.relation.journalFEBS LETTERS-
dc.contributor.googleauthorSon, LT-
dc.contributor.googleauthorChoi, T.-W-
dc.contributor.googleauthorLee, S.-K-
dc.contributor.googleauthorAhnn, J-
dc.contributor.googleauthorKo, K.-M-
dc.contributor.googleauthorSong, H.-O-
dc.contributor.googleauthorCho, J.H-
dc.contributor.googleauthorSingaravelu, G-
dc.contributor.googleauthorChatterjee, I-
dc.contributor.googleauthorYu, J.-R-
dc.contributor.googleauthorPark, B.-J-
dc.relation.code2011203177-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjoohong-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE