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DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans

Title
DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans
Other Titles
L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans
Author
안주홍
Keywords
dhs-21; L-Xylulose reductase; Longevity; Egg-laying; Gene expression
Issue Date
2011-05
Publisher
Elsevier Science B.V., Amsterdam
Citation
FEBS Letters 6 May 2011, 585(9),1310-1316
Abstract
Dicarbonyl/L-xylulose reductase (DCXR) converts L-xylulose into xylitol, and reduces variousa-dicar-bonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxi?cation. Inthis study, we identi?ed DHS-21 as the only DCXR ortholog in Caenorhabditis elegans. The dhs-21gene is expressed in various tissues including the intestine, gonadal sheath cells, uterine seam (utse)cells, the spermathecal-uterus (sp-ut) valve and on the plasma membrane of spermatids. Recombi-nant DHS-21 was shown to convertL-xylulose to xylitol using NADPH as a cofactor. Dhs-21 mutants of C. elegans show defects in longevity, reproduction and egg-laying. Knock-down of daf-16 and elt-2 transcription factors affected dhs-21 expression. These results suggest that DHS-21 isa bona ?de DCXR of C. elegans, essential for normal life span and reproduction.
URI
http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2011.03.062/abstract
ISSN
0014-5793
DOI
10.1016/j.febslet.2011.03.062
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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