86 0

Determination of acetaminophen by electrochemical co-deposition of glutamic acid and gold nanoparticles

Title
Determination of acetaminophen by electrochemical co-deposition of glutamic acid and gold nanoparticles
Author
성기훈
Keywords
Acetaminophen; Ascorbic acid; Single-walled carbon nanotube; Gold nanoparticle; Glutamic acid; Differential pulse voltammetry
Issue Date
2012-09
Publisher
Elsevier Science SA
Citation
Sensors & Actuators: B. Chemical, Nov 2012, 174, P.318-324
Abstract
We developed an electrochemical sensor to detect acetaminophen by electrochemically co-depositing glutamic acid and gold nanoparticles on a single-walled carbon nanotube film (AuNP-PGA/SWCNT). Cyclic voltammetry indicated that the electrochemical oxidation of acetaminophen at the AuNP-PGA/SWCNT film electrode involved a two-electron, one-proton process and was pH dependent. Different pulse voltammograms of acetaminophen oxidation on the AuNP-PGA/SWCNT film electrode yielded a well-defined oxidation peak at 360 mV in 0.1 M phosphate buffered saline buffer (pH 7.2) with linear calibration from 8.3 to 145.6 mu M (R-2=0.997). The detection limit was estimated to be 1.18 mu M. The proposed sensor is stable and reproducible from 1.15 to 5.21% with a relative standard deviation of 3.56%. The AuNP-PGA/SWCNT film electrode was able to detect acetaminophen in the presence of interfering ascorbic acid; two well-defined oxidation peaks, one for ascorbic acid at 0.15V and the other for acetaminophen at 0.39V, were detected. Furthermore, the fabricated sensor accurately measured the amount of acetaminophen in pharmaceutical samples. Together, these results indicate that our AuNP-PGA/SWCNT film is a promising platform for accurate and reproducible detection of acetaminophen.
URI
https://www.sciencedirect.com/science/article/pii/S092540051200826X?via%3Dihub
ISSN
0925-4005
DOI
10.1016/j.snb.2012.08.012
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE