Synthesis of stereochemically diverse cyclic analogs of tubulysins
- Title
- Synthesis of stereochemically diverse cyclic analogs of tubulysins
- Author
- 하정미
- Keywords
- Tubulysin; Antitumor agents; Peptides; Asymmetric catalysis; Hetero Diels-Alder reaction; SIMPLIFIED PRETUBULYSIN DERIVATIVES; N-METHYLAMINO ACIDS; BIOLOGICAL EVALUATION; BOND FORMATION; RACEMIZATION; CYTOTOXICITY; MYXOBACTERIA; DANISHEFSKYS; ANTICANCER; INHIBITORS
- Issue Date
- 2015-11
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY, v. 23, No. 21, Page. 6827-6843
- Abstract
- The synthesis of tubulysin analogs containing stereochemically diverse cyclic Tuv moieties is described. A tetrahydropyranyl moiety was incorporated into the Tuv unit by enantioselective hetero Diels-Alder reactions of Danishefsky's diene and thiazole aldehyde. Four different stereoisomers of cyclic Tuv units were used as surrogates for the Tuv moiety. The synthesized stereochemically diverse simplified cyclic analogs were evaluated for the inhibition of tubulin polymerization. (C) 2015 Elsevier Ltd. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S096808961530081Xhttp://hdl.handle.net/20.500.11754/41012
- ISSN
- 0968-0896; 1464-3391
- DOI
- 10.1016/j.bmc.2015.10.003
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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