Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2018-02-28T01:22:33Z | - |
dc.date.available | 2018-02-28T01:22:33Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, v. 83, No. 3-4, Page. 355-361 | en_US |
dc.identifier.issn | 1388-3127 | - |
dc.identifier.issn | 1573-1111 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s10847-015-0571-2 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/40944 | - |
dc.description.abstract | In this study, the anticancer effect and improved safety for hypesensitivity reactions of docetaxel/hydroxypropyl-beta-cyclodextrin complex (DCX-CD) were investigated. The preparation of DCX-CD was confirmed by using differential scanning calorimetry, X-ray powder diffraction analysis, and scanning electron microscope. The anticancer activity was tested in human lung cancer A549 cell-transplanted mice and the hypersensitivity was tested in Beagle dogs after intravenous administration of DCX-CD, Taxotere, and their respective vehicles. In the hypersensitivity test, plasma histamine levels were determined using an ELISA method. Our results showed that DCX-CD was pharmacologically equivalent to Taxotere. Furthermore, DCX-CD did not cause the release of histamines or any significant symptoms associated with hypersensitivity. These results suggested that DCX-CD could be a promising alternative to Taxotere for cancer chemotherapy with reduced side effects. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry (NRF-2014R1A1A1A 05002840). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Docetaxel | en_US |
dc.subject | HP-beta-CD | en_US |
dc.subject | Anticancer activity | en_US |
dc.subject | Hypersensitivity | en_US |
dc.subject | DOCETAXEL FORMULATION | en_US |
dc.subject | TAXOTERE | en_US |
dc.subject | SID530 | en_US |
dc.subject | PHARMACOKINETICS | en_US |
dc.subject | BINDING | en_US |
dc.subject | SAFETY | en_US |
dc.subject | PLASMA | en_US |
dc.title | Anticancer effect of docetaxel/hydroxypropyl-beta-cyclodextrin complex without histamine release | en_US |
dc.type | Article | en_US |
dc.relation.no | 3-4 | - |
dc.relation.volume | 83 | - |
dc.identifier.doi | 10.1007/s10847-015-0571-2 | - |
dc.relation.page | 355-361 | - |
dc.relation.journal | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | - |
dc.contributor.googleauthor | Kim, Tae Kon | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.relation.code | 2015002778 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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