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Anticancer effect of docetaxel/hydroxypropyl-beta-cyclodextrin complex without histamine release

Title
Anticancer effect of docetaxel/hydroxypropyl-beta-cyclodextrin complex without histamine release
Author
유혜현
Keywords
Docetaxel; HP-beta-CD; Anticancer activity; Hypersensitivity; DOCETAXEL FORMULATION; TAXOTERE; SID530; PHARMACOKINETICS; BINDING; SAFETY; PLASMA
Issue Date
2015-12
Publisher
SPRINGER
Citation
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, v. 83, No. 3-4, Page. 355-361
Abstract
In this study, the anticancer effect and improved safety for hypesensitivity reactions of docetaxel/hydroxypropyl-beta-cyclodextrin complex (DCX-CD) were investigated. The preparation of DCX-CD was confirmed by using differential scanning calorimetry, X-ray powder diffraction analysis, and scanning electron microscope. The anticancer activity was tested in human lung cancer A549 cell-transplanted mice and the hypersensitivity was tested in Beagle dogs after intravenous administration of DCX-CD, Taxotere, and their respective vehicles. In the hypersensitivity test, plasma histamine levels were determined using an ELISA method. Our results showed that DCX-CD was pharmacologically equivalent to Taxotere. Furthermore, DCX-CD did not cause the release of histamines or any significant symptoms associated with hypersensitivity. These results suggested that DCX-CD could be a promising alternative to Taxotere for cancer chemotherapy with reduced side effects.
URI
https://link.springer.com/article/10.1007/s10847-015-0571-2http://hdl.handle.net/20.500.11754/40944
ISSN
1388-3127; 1573-1111
DOI
10.1007/s10847-015-0571-2
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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