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The Potential of Adaptive Design in Animal Studies

Title
The Potential of Adaptive Design in Animal Studies
Author
배옥남
Keywords
adaptive design; animal studies; preclinical research; CLINICAL-TRIAL DESIGN; DRUG DEVELOPMENT; CHALLENGES
Issue Date
2015-10
Publisher
MDPI AG
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 16, No. 10, Page. 24048-24058
Abstract
Clinical trials are the backbone of medical research, and are often the last step in the development of new therapies for use in patients. Prior to human testing, however, preclinical studies using animal subjects are usually performed in order to provide initial data on the safety and effectiveness of prospective treatments. These studies can be costly and time consuming, and may also raise concerns about the ethical treatment of animals when potentially harmful procedures are involved. Adaptive design is a process by which the methods used in a study may be altered while it is being conducted in response to preliminary data or other new information. Adaptive design has been shown to be useful in reducing the time and costs associated with clinical trials, and may provide similar benefits in preclinical animal studies. The purpose of this review is to summarize various aspects of adaptive design and evaluate its potential for use in preclinical research.
URI
http://www.mdpi.com/1422-0067/16/10/24048/htmhttp://hdl.handle.net/20.500.11754/40520
ISSN
1422-0067
DOI
10.3390/ijms161024048
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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