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dc.contributor.author김미경-
dc.date.accessioned2018-02-23T00:36:04Z-
dc.date.available2018-02-23T00:36:04Z-
dc.date.issued2016-03-
dc.identifier.citationEUROPEAN JOURNAL OF NUTRITION, v. 55, NO 2, Page. 855-866en_US
dc.identifier.issn1436-6207-
dc.identifier.issn1436-6215-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00394-015-0896-z-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/40237-
dc.description.abstractThe interaction between genetics and diet may explain the present disagreement in the protective role of vitamin intake on cardiovascular disease. We cross-sectionally assessed the interaction of habitual dietary intake of beta-carotene, vitamin C, folate, and vitamin E with single nucleotide polymorphisms (SNPs) on brachial-ankle pulse wave velocity (baPWV), a measure of arterial stiffness. Dietary intakes of beta-carotene, vitamin C, folate, and vitamin E were quantified by a food frequency questionnaire in 3198 healthy men and women (a parts per thousand yen40 years) from the Korea Multi-Rural communities Cohort study. baPWV was measured, and 19 SNPs were genotyped. The associations and interactions between dietary vitamin intake, SNP genotype, and baPWV were assessed using general linear models. In both men and women, dietary intake of beta-carotene, vitamin C, folate, or vitamin E and baPWV were not directly associated. Vitamin C, folate, and vitamin E intake had an interaction with rs4961 (ADD1) genotype on baPWV in men. rs4961 also interacted with folate intake on baPWV in women. In women, rs10817542 (ZNF618) and rs719856 (CD2AP) had an interaction with beta-carotene and folate intake and rs5443 (GNB3) had an interaction with vitamin E intake on baPWV. In general, minor allele homozygotes with low vitamin intake had higher baPWV than other subgroups. Results were similar when supplement users were excluded. Higher intake of dietary vitamin C, folate, and vitamin E may be related to high baPWV in healthy Korean men who are minor allele homozygotes of rs4961. In healthy Korean women, dietary folate, beta-carotene, and vitamin E intake may affect baPWV differently according to rs4961, rs10817542, rs719856, or rs5443 genotype. Greater dietary intake of these nutrients may protect those that are genetically vulnerable to stiffening of the arteries.en_US
dc.description.sponsorshipThis study was provided with biospecimens and data from the Korean Genome Analysis Project (4845-301) and the Korean Genome and Epidemiology Study (4851-302) that was supported by a Research of Korea Centers for Disease Control and Prevention, Republic of Korea. This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (grant NRF-2012R1A1A2001930).en_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.subjectVitamin intakeen_US
dc.subjectGene-nutrient interactionen_US
dc.subjectArterial stiffnessen_US
dc.subjectPulse wave velocityen_US
dc.subjectCross-sectional studyen_US
dc.titleHabitual dietary intake of beta-carotene, vitamin C, folate, or vitamin E may interact with single nucleotide polymorphisms on brachial-ankle pulse wave velocity in healthy adultsen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume55-
dc.identifier.doi10.1007/s00394-015-0896-z-
dc.relation.page855-866-
dc.relation.journalEUROPEAN JOURNAL OF NUTRITION-
dc.contributor.googleauthorPark, Clara Yongjoo-
dc.contributor.googleauthorJung, Sukyoung-
dc.contributor.googleauthorKim, Mi Kyung-
dc.contributor.googleauthorChoi, Bo Youl-
dc.contributor.googleauthorShin, Min-Ho-
dc.contributor.googleauthorShin, Dong Hoon-
dc.contributor.googleauthorLee, Young-Hoon-
dc.contributor.googleauthorChun, Byung-Yeol-
dc.contributor.googleauthorHong, Kyung-Won-
dc.contributor.googleauthorHwang, Joo-Yeon-
dc.relation.code2016009192-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkmkkim-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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