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dc.contributor.author박준성-
dc.date.accessioned2018-02-22T13:43:49Z-
dc.date.available2018-02-22T13:43:49Z-
dc.date.issued2012-09-
dc.identifier.citationKidney & blood pressure research, Vol.35 No.6 [2012],p.627-633en_US
dc.identifier.issn1420-4096-
dc.identifier.urihttps://www.karger.com/Article/FullText/341124-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/40190-
dc.description.abstractBackground/Aims: Subclinical hypovolemia may contribute to allograft dysfunction in long-term kidney transplant (KT) patients. In order to predict responsiveness to saline hydration, indices for tubular transport were investigated. Methods: Fifty-four clinically euvolemic long-term KT patients with recently aggravated azotemia were given intravenous hydration as follows: 0.9% saline 5 ml/kg over 1 h, followed by 0.9% saline 1 ml/kg/h over 12 h and 1 liter of 0.45% saline over the next 24 h. Serum and urine data were collected and analyzed to assess responses. Results: In all patients, saline hydration relieved azotemia, as shown by blood urea nitrogen (46.9 +/- 17.2 vs. 39.3 +/- 15.4 mg/dl; p < 0.01) and serum creatinine levels (2.9 +/- 1.1 vs. 2.5 +/- 1.1 mg/dl; p < 0.01) on day 0 versus day 2. In 38 patients, serum creatinine did not increase in the following month (70% responders). Compared with the nonresponders, the responders had a higher urine-to-plasma creatinine ratio and lower fractional excretion of sodium, uric acid and urea at admission. Multivariate logistic regression analysis revealed that responsiveness to saline hydration was independently associated with lower fractional excretion of uric acid. Conclusion: Subclinical hypovolemia should be considered in long-term KT patients with azotemia of unexplainable causes. Fractional excretion of uric acid may predict responsiveness to saline hydration.en_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.subjectAcute kidney injuryen_US
dc.subjectKidney transplantationen_US
dc.subjectTubular transporten_US
dc.subjectUric aciden_US
dc.titleFractional Excretion of Uric Acid as a Predictor for Saline Responsiveness in Long-Term Kidney Transplant Patientsen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume35-
dc.identifier.doi10.1159/000341124-
dc.relation.page627-633-
dc.relation.journalKIDNEY & BLOOD PRESSURE RESEARCH-
dc.contributor.googleauthorChoi, Jong-Wook-
dc.contributor.googleauthorPark, Joon-Sung-
dc.contributor.googleauthorKoo, Tai Yeon-
dc.contributor.googleauthorLee, Chang Hwa-
dc.contributor.googleauthorKang, Chong Myung-
dc.contributor.googleauthorKim, Gheun-Ho-
dc.relation.code2012206186-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidsjpjoon-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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