Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이양순 | - |
dc.date.accessioned | 2018-02-22T08:03:20Z | - |
dc.date.available | 2018-02-22T08:03:20Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | Clinical and Laboratory Science. Annals, 2012, 42(3), P.281-286 | en_US |
dc.identifier.issn | 2296-4616 | - |
dc.identifier.issn | 0091-7370 | - |
dc.identifier.issn | 1550-8080 | - |
dc.identifier.uri | http://www.annclinlabsci.org/content/42/3/281.full | - |
dc.description.abstract | We investigated the molecular mechanisms of carbapenem resistance in clinical isolates of Enterobacter cloacae and their clinical characteristics. Nonreplicable E cloacae isolates were recovered from six cancer patients and one patient with liver cirrhosis at a tertiary-care hospital in Korea between 2002 and 2009. Two patients who were considered to have a true infection caused by these microorganisms have died. All isolates produced AmpC beta-lactamases, including ACT-1, ACT-2, MIR-3 and DHA-1, and CTX-M- or SHV-type extended-spectrum beta-lactamase. Two isolates produced plasmid-borne VIM-2 carbapenemase. All probes specific for bla(AmpC) genes hybridized with 1-CeuI chromosomal fragments were also recognized by a probe specific for 16S rDNA, suggesting a chromosomal location. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that a major outer membrane protein, OmpF, was absent in all isolates. PFGE of XbaI-digested DNA were considered to be unrelated. The results of our study suggest that the chromosomal AmpC beta-lactamase with impermeability in E. cloacae clinical isolates implicated in reduced carbapenem susceptibility. Although carbapenem-resistant E. cloacae isolates were isolated in a few patients in our study, the clinical outcomes were grave. Therefore, the patients colonized or infected by carbapenem-resistant E. cloacae isolates should gain attention of antibiotic therapy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ASSOC Clinical Scientists | en_US |
dc.subject | METALLO-BETA-LACTAMASE | en_US |
dc.subject | KLEBSIELLA-PNEUMONIAE | en_US |
dc.subject | ESCHERICHIA-COLI | en_US |
dc.subject | PORIN | en_US |
dc.subject | PLASMID | en_US |
dc.subject | GENE | en_US |
dc.subject | SUSCEPTIBILITY | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | EMERGENCE | en_US |
dc.subject | ERTAPENEM | en_US |
dc.title | Molecular Mechanisms of Carbapenem Resistance in Enterobacter cloacae Clinical Isolates from Korea and Clinical Outcome | en_US |
dc.type | Article | en_US |
dc.relation.volume | 42 | - |
dc.relation.page | 281-286 | - |
dc.relation.journal | ANNALS OF CLINICAL AND LABORATORY SCIENCE | - |
dc.contributor.googleauthor | Lee, Yangsoon | - |
dc.contributor.googleauthor | Kang, Girung | - |
dc.contributor.googleauthor | Bae, Il Kwon | - |
dc.contributor.googleauthor | Jeong, Seok Hoon | - |
dc.contributor.googleauthor | Lee, Kyungwon | - |
dc.contributor.googleauthor | Choi, Heekyeong | - |
dc.contributor.googleauthor | Yum, Jong Hwa | - |
dc.contributor.googleauthor | 이양순 | - |
dc.contributor.googleauthor | 강기륭 | - |
dc.contributor.googleauthor | 배일권 | - |
dc.contributor.googleauthor | 정석훈 | - |
dc.contributor.googleauthor | 이경원 | - |
dc.contributor.googleauthor | 최희경 | - |
dc.contributor.googleauthor | 염종화 | - |
dc.relation.code | 2012200682 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yangsoon | - |
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