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dc.contributor.author신진호-
dc.date.accessioned2018-02-22T07:38:41Z-
dc.date.available2018-02-22T07:38:41Z-
dc.date.issued2011-10-
dc.identifier.citationCardiovascular Diabetology. (Cardiovascular Diabetology, 17 October 2011, 10)en_US
dc.identifier.issn1475-2840-
dc.identifier.urihttps://cardiab.biomedcentral.com/articles/10.1186/1475-2840-10-92-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/39888-
dc.description.abstractBackground: Diabetic cardiomyopathy (CMP) is a common and disabling disease 0000218C in diabetic patients, however no effective treatments have been developed. Although granulocyte-colony stimulating factor (G-CSF) improves heart function in myocardial infarction, its effect on non-ischemic CMP such as diabetic CMP is unknown. In the present study, we investigated the effects of G-CSF on diabetic CMP in a rat model of type II diabetes. Methods: Twenty 7-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF: a rat model of diabetes) rats and 10 male Long-Evans Tokushima Otsuka (LETO: normal controls) rats were used. All of the LETO and 8 OLETF rats were fed on tap water while the rest were fed on sucrose-containing water. After 10 weeks, saline or recombinant human G-CSF (100 mu g/kg/day) was injected intraperitoneally for 5 days. Blood levels of glucose, total cholesterol and triglyceride, and Doppler echocardiograms for diastolic dysfunction were obtained just before and 4 weeks after the saline or G-CSF treatment. Light microscopy, electron microscopy (EM) and immunohistochemistry for transforming growth factor-beta were employed to examine myocardial histology 4 weeks after the saline or G-CSF treatment. Results: Diastolic dysfunction developed at 17 weeks (before the saline or G-CSF treatment) in the OLETF rats whether or not they were fed sucrose water, but were more severe in those fed sucrose water. Four weeks after saline or G-CSF treatment, diastolic function had recovered in the G-CSF-treated group regardless of sucrose water feeding, and perivascular and/or interstitial fibrosis in the G-CSF-treated group had decreased significantly. TGF-beta immunoreactivity in the interstitial and perivascular tissue was also reduced in the G-CSF-treated group, and EM studies revealed less severe disruption of myofilaments and mitochondrial cristae, and decreased collagen deposition. Conclusions: G-CSF can ameliorate cardiac diastolic dysfunction and morphological damage, especially fibrosis of the myocardium, in OLETF rats with diabetic CMP.en_US
dc.description.sponsorshipThis work was supported by the grant for the Medical Research Center (2011-0028261) funded by the National Research Foundation of Korea (NRF) of the Ministry of Education, Science and Technology (MEST), Republic of Korea.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.,en_US
dc.subjectDiabetes Mellitusen_US
dc.subjectCardiomyopathyen_US
dc.subjectEchocardiographyen_US
dc.subjectDoppleren_US
dc.subjectHistologyen_US
dc.subjectFibrosisen_US
dc.titleEffects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty ratsen_US
dc.typeArticleen_US
dc.relation.volume10-
dc.identifier.doi10.1186/1475-2840-10-92-
dc.relation.page--
dc.relation.journalCARDIOVASCULAR DIABETOLOGY-
dc.contributor.googleauthorLim, Young-Hyo-
dc.contributor.googleauthorJoe, Jun-Ho-
dc.contributor.googleauthorSong, Yi-Sun-
dc.contributor.googleauthorSo, Byung-Im-
dc.contributor.googleauthorFang, Cheng-Hu-
dc.contributor.googleauthorShin, Jinho-
dc.contributor.googleauthor(Kim, Jung-Hyun-
dc.contributor.googleauthorLim, Heon-Kil-
dc.contributor.googleauthorKim, Kyung-Soo-
dc.contributor.googleauthorJang, Ki-Seok-
dc.relation.code2011217858-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjhs2003-


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